摘要
目的建立年轻SD大鼠单侧髁突颈部截骨、骨折的动物模型,探讨应力改变明显致大鼠下颌骨髁突生长发育受到影响时,下颌骨偏斜程度的变化。方法 72只雄性SD大鼠按完全随机法分3组,每组24只,建立大鼠单侧髁突颈部横行截骨、骨折的动物模型,观察截骨组、骨折组、对照组术后1、3、5、9周下颌骨偏斜程度的变化。结果截骨组、骨折组术后在4个时间点下颌骨均向手术侧偏斜,α值均小于对照组,差异有统计学意义(P<0.05),截骨组与骨折组之间差异无统计学意义(P>0.05)。截骨组手术侧术后1周髁突区膨大,大量增生的软组织包裹。术后3周髁突头呈缩小趋势,术后5、9周髁突变窄而高。骨折组手术侧术后1周髁突呈圆柱状,见骨折线。术后3、5、9周,髁突圆柱状呈缩小趋势,但缩小程度不如截骨组手术侧。结论单侧髁突颈截骨相对骨折,影响下颌骨及髁突生长发育,但两组的下颌骨偏斜程度无影响。
Objective To establish unilateral condylar neck osteotomy and fracture in SD rats model,and discuss the effect of significant stress changes on the growth and development of mandible in SD rats： Methods Seventy-two SD rats were randomly divided into 3 groups, 24 for each group,including unilateral condylar process osteotomy group, fracture group, un-operated blank con- trol group. The changes of asymmetric mandibular were observed 1,3,5,9 weeks after operation. Results The mandibular of osteotomy group and fracture group deflected on the operation side in the four times,and the a value was small than control one, with significant difference（P〈0.05）. But the mandibular of osteotomy group was not different from fracture group（P〉0.05）. In osteotomy group, the growth and development of condyle in osteotomy side was enlargement after 1 week, enclosed with proliferation of soft tlssues,and became shrinkage after 3 weeks, narrower and higher after 5,9. weeks. While in fracture group, it happened with columned condyle one week after operation, which could see the fracture line, and the columned condyle showed a decrease trend, but the extent of shrinkage was less than the osteotomy group. Conclusion The osteotomy compared with the fracture produces a series of physical responses in the mandibular and condyle, but has no influence in the asymmetric extent of mandible.
出处
《重庆医学》
CAS
CSCD
北大核心
2013年第19期2191-2193,2197,共4页
Chongqing medicine
基金
国家自然科学基金面上项目(30960426)
云南省科技厅-昆明医学院应用基础联合专项资金项目(2008C0060R)
无锡医管中心发展基金面上项目(YGM1104)
关键词
下颌骨
截骨术
骨折
偏斜
髁突
mandible
osteotomy
fractures, bone
asymmetric
condyle
