摘要
目的探讨广东汉族人群缝隙连接蛋白37(Cx37)基因多态性与动脉粥样硬化性脑梗死的关系。方法应用SNaPshot技术,检测250例动脉粥样硬化性脑梗死患者(病例组)和200例健康人(对照组)的Cx37基因rs1764391多态位点的基因型和等位基因频率。结果病例组与对照组Cx37基因的多态位点rs1764391的基因型分布无统计学意义(P=0.217);病例组的T等位基因频率高于对照组(22.4%vs 17.7%,P=0.085);病例组中,TT+CT基因型(T等位基因携带者)的颈总动脉内膜-中膜厚度大于CC基因型,差异有统计学意义(P=0.032)。结论广东汉族人群Cx37基因的多态位点rs1764391与动脉粥样硬化性脑梗死无关,T等位基因增加颈总动脉内膜-中膜厚度。
Objective To explore the relationship between connexin 37 gene polymorphisms and atherosclerotic cerebral infarction（ACI） in Han Guangdong population.Methods Genomic DNA was isolated from 250 patients with ACI and 200 healthy controls.All subjects were genotyped for rs1764391 in the connexin 37 gene using SNaPshot technique.Results No significant differences were found in the distribution of genotypes（P= 0.217） of rs1764391 between patients and controls.Additionally,the T allele frequencies of rs1764391 in ACI patients were more higher compared to healthy controls（22.4% vs 17.7%,P=0.085）.Furthermore,among ACI patients,the carotid artery intima-media thickness of TT＋CT genotypes（T allele carrier） was more significantly thicker compared to CC genotypes（P=0.032）.Conclusion Rs1764391 in the connexin 37 gene do not influence the risk of ACI in Han Guangdong population.However,the T allele increases the carotid artery intima-media thickness.
出处
《中风与神经疾病杂志》
CAS
CSCD
北大核心
2013年第6期524-527,共4页
Journal of Apoplexy and Nervous Diseases
