摘要
目的:对中药5类新药苍术总萜醇的化学组成进行研究。方法:通过气相色谱-质谱联用技术对苍术总萜醇的化学成分进行分析、鉴定。结果:从苍术总萜醇中鉴定出20个组分,其中相对含量>1%的组分为茅术醇、β-桉叶醇、γ-桉叶醇、榄香醇和2,3-Dihydro-1-oxo-phenalene,且茅术醇和β-桉叶醇两组分的相对含量之和为87%。结论:苍术总萜醇中茅术醇和β-桉叶醇两组分含量最高。苍术总萜醇除含有倍半萜醇类成分外,还含有倍半萜烯类成分。茅术醇是质子泵抑制剂,β-桉叶醇是组胺H2受体阻断剂,两个倍半萜醇类化合物协同作用而抑制胃液分泌,从而发挥抗溃疡的作用。
Objective： To study chemical constituents of the fifth sort of new drugs-total terpene alcohols of Atractylodes lances.Method： Using GC-MS as the method,the chemical constituents were analyzed and identified.Result： Twenty components were identified from the total terpene alcohols of A.lances,and the relative contents 1% of the group were divided into hinesol,β-eudesmol,γ-eudesmol,rugby alcohol and 2,3-Dihydro1-oxo-phenalene,which hinesol and β-eudesmol were 87%.Conclusion： The total terpene alcohols of A.lances has the highest contents of hinesol and β-eudesmol,and in addition to sesquiterpene alcohol compositions,it also contains sesquiterpene alkene components.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第13期100-102,共3页
Chinese Journal of Experimental Traditional Medical Formulae
基金
2008年深圳市产学研究公共技术平台项目
2009年深圳市南山区科技研发资金企业研发项目
关键词
五类新药
苍术
总萜醇
气相色谱-质谱
the fifth sort of new drugs
Atractylodes lances
total terpene alcohols
GC-MS
