摘要
目的探讨颈动脉粥样硬化及血清炎症因子与老年2型糖尿病合并无症状性脑梗死的关系。方法选择62例老年单纯无症状脑梗死患者为A组,选择68例老年2型糖尿病合并无症状脑梗死患者为B组,同时选取60例健康者为对照组,比较3组颈动脉粥样硬化斑块检出率及血清炎症因子水平。结果对照组、A组及B组颈动脉中层厚度(IMT)及颈动脉粥样硬化检出率依次增加,差异有统计学意义(P<0.05);A、B组不稳定斑块检出率显著高于对照组(P<0.05),但2组比较差异无统计学意义(P>0.05);对照组、A组及B组血清超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平依次升高(P<0.05)。结论炎症因子参与老年无症状脑梗死的发生及颈动脉粥样硬化形成过程,合并糖尿病者炎症反应更为严重。
Objective To explore the relationship between carotid artery atherosclerosis and inflammatory factors with elderly type 2 diabetes mellitus complicated with asymptomatic cerebral infarction.Methods Totally 62 elderly patients with asymptomatic cerebral infarction were selected as group A,68 elderly cases of type 2 diabetes mellitus complicated with asymptomatic cerebral infarction as group B and 60 healthy persons as control group.Detection rate of carotid artery atherosclerosis plaque and serum inflammatory factors were compared between two groups.Results IMT and detection rate of carotid artery atherosclerosis plaque gradually increased in control group,group A and group B with significant difference（P0.05）.Detection rates of unstable plaque in group A and group B were much higher than those in control group（P0.05）,but without significant difference between group A and group B（P0.05）.In control group,group A and group B,serum hs-CRP,TNF-αand IL-6 gradually increased（P0.05）.Conclusion Inflammatory factors participate in the pathogenesis of carotid artery atherosclerosis.Inflammatory response is more severe in type 2 diabetes mellitus complicated with asymptomatic cerebral infarction patients.
出处
《中国实用神经疾病杂志》
2013年第11期35-36,共2页
Chinese Journal of Practical Nervous Diseases
关键词
无症状性脑梗死
2型糖尿病
颈动脉粥样硬化
炎症因子
Asymptomatic cerebral infarction
Type 2 diabetes mellitus
Carotid artery atherosclerosis
Inflammatory factors
