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不孕症合并代谢综合征患者子宫内膜息肉发生情况及机制探讨 被引量:6

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摘要 目的观察不孕症合并代谢综合征患者子宫内膜息肉(EP)的发生情况,并探讨代谢综合征与EP发病的关系。方法行宫腔镜检查的不孕症患者130例,分为代谢综合征组(A组,52例)及非代谢综合征组(B组,78例),记录两组EP发生情况,比较两组体质量指数(BMI)、腰围、腰臀比、血压、性激素(FSH、LH、E2、T)、空腹血糖(FPG)、血脂(TG、HDL-C、LDL-C)、空腹胰岛素(FINS)、稳态模型胰岛素抵抗指数(HOMA-IR)。结果 A组EP发生率(48.08%)高于B组(15.38%),P<0.05;A组BMI、腰围、腰臀比、血压、FPG、TG、FINS、HOMA-IR、T水平均高于B组,HDL-C水平低于B组(P均<0.05)。A组胰岛素抵抗发生率(48.1%)高于B组(21.0%),P<0.05。结论不孕症患者中,合并代谢综合征者EP发生率高于非代谢综合征患者,代谢综合征者长期持续的无孕激素拮抗的单一雌激素水平升高、高雄激素血症、伴胰岛素抵抗的高胰岛素血症与EP的发病有关。
出处 《山东医药》 CAS 2013年第18期59-61,共3页 Shandong Medical Journal
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参考文献12

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