摘要
目的研究子宫内膜息肉患者的息肉组织中雌激素受体(ER)、孕激素受体(PR)的表达,进一步阐明子宫内膜息肉的发生机制。方法子宫内膜息肉组患者40例,设为内膜息肉组;同期选择24例输卵管因素不孕者作为对照组。两组患者取材前半年未曾口服任何激素类药物。用免疫组化方法检测两组患者子宫内膜组织中ER、PR的表达,同时在月经第3～5天进行血抑制素B(INH-B)、促卵泡素(FSH)、雌激素(E)和孕激素(P)的检测。结果ER、PR在内膜息肉组和对照组中均有表达。PR在内膜息肉组中腺上皮细胞(3.050±0.714)和间质细胞(2.850±0.700)的表达显著低于对照组中腺上皮细胞(3.542±0.588)和间质细胞(3.417±0.654)的表达(U腺上皮细胞=-2.695,P<0.05;U间质细胞=-3.082,P<0.05)。血FSH、E、P水平在子宫内膜息肉组分别为(7.84±2.64)nmol/L、(181.78±105.48)nmol/L、(4.09±3.65)pmol/L,对照组分别为(7.25±1.73)nmol/L、(183.13±78.27)nmol/L、(2.84±0.91)pmol/L,差异均无统计学意义(tFSH=0.761,P>0.05;tE=0.06,P>0.05;tP=1.694,P>0.05)。结论子宫内膜息肉组织中PR的表达较正常增殖期子宫内膜组织表达低,而使孕酮对子宫内膜增殖的负调控作用减弱,PR可能参与了息肉形成的病理过程。
Objective To detect the expression of estrogen recptors （ER） and progestogen recptors （PR） in endometrial polyps （EP）. Methods Forty endometrial specimens from patients with endometrial polyps and 24 specimens of normal proliferative endometrium from patients with salpingo-infertility were collected; all patient had no any steroid administrations 6 months before the study. Expression of ER, PR in EP and proliferative endometrial tissues were detected by immunohistochemistry; and blood samples were tested for FSH, estrogen （E） and progestogen （P）. Results Both ER and PR were expressed in normal endometrial tissues and in EP tissues. And the expression of PR in EP tissues was lower than that in proliferative endometrial tissues （P〈0.05）.There were no significant differences in blood FSH, estrogen and progestogen levels between patients with salpingo-infertility and EP （P〉0.05）. Conclusion Low expression of PR in proliferative phase might be involved in pathogenesis of EP.
出处
《浙江医学》
CAS
2008年第2期120-122,共3页
Zhejiang Medical Journal
