摘要
目的:观察5-氟尿嘧啶与异维甲酸联合用药治疗妇科尖锐湿疣的疗效。方法:将门诊收治的141例尖锐湿疣患者随机分为5-氟尿嘧啶组、异维甲酸组及联用组,每组47例,分别给予2.5%的5-氟尿嘧啶注射或涂抹、口服异维甲酸胶囊10mg及两药联用,观察治疗后2周内疗效及10个月内复发情况和不良反应。结果:5-氟尿嘧啶组、异维甲酸组、联用组2周内总有效率分别为93.6%、91.5%、97.9%,差异无统计学意义(P>0.05),不良反应发生率分别为8.5%、6.4%、10.6%,差异无统计学意义(P>0.05);2个月内和4个月内联用组的复发率分别为14.9%、2.1%,均显著低于5-氟尿嘧啶组(分别为44.7%、17.0%)和异维甲酸组(分别为38.3%、19.1%)(P<0.05)。结论:单用5-氟尿嘧啶或异维甲酸4个月内的抑制复发效果并不理想,5-氟尿嘧啶与异维甲酸联合用药则能有效在前4个月内抑制复发。
OBJECTIVE： To observe therapeutic efficacy of 5-fluorouracil and isotretinoin in the treatment of gynecological con-dyloma acuminatum. METHODS： 141 cases of condyloma acuminatum which admitted in outpatient department were randomized into 5-fluorouracil group, isotretinoin group and combination group with 47 cases in each group. They were given 2.5% 5-fluoroura-cil injection or oral dose, smear administration of 10 mg Isotretinoin capsule, two-drug combination respectirely. Curative effects of them were observed within 2 weeks, and recurrence rate and adverse drug reactions were observed within 10 months. RESULTS： After 2 weeks of treatment, the total effective rates of 3 groups were 93.6%, 91.5% and 97.9% ; there was no statistical signifi-cance （P〉 0.05）. The incidence of adverse drug reactions were 8.5%, 6.4% and 10.6%; there was no statistical significance （P〉 0.05）. After 2 and 4 months of treatment, the recurrence rates of combination group were 14.9% and 2.1%, which were lower than those （44.7%, 17.0% ） of 5-fluorouracil group and those （38.3%, 19.1% ） of isotretinoin group （P〈0.05）. CONCLU-SIONS： Inhibitory effects of 5-fluorouracil or isotretinoin alone on recurrence of condyloma acuminatum are unsatisfactory; com-bined use of 2 drugs will have an effective inhibitory effect on recurrence of condyloma acuminatum on the first four months.
出处
《中国药房》
CAS
CSCD
2013年第26期2452-2454,共3页
China Pharmacy
关键词
妇科
尖锐湿疣
5-氟尿嘧啶
异维甲酸
复发
Gynecology
Condyloma acuminatum
5-fluorouracil
Isotretinoin
Recurrence
