摘要
目的分析盐酸莫西沙星在人体内的血药浓度及药动学。方法 10名志愿受试者单剂量口服莫西沙星400mg后,采用固相萃取-高效液相色谱方法测定盐酸莫西沙星的血药浓度及药动学参数,用DAS2.0软件自动拟合处理,计算药动学参数。结果莫西沙星的药动参数:t1/2α=(5.26±0.20)h;t1/2β=(7.80±0.50)h;AUC(0～t)=(111.8±10.3)μg/(mL.h);tmax=(3.13±0.32)h;Cmax=(13.5±0.42)μg/mL;莫西沙星在体内的药-时曲线符合二室开放模型,在体内消除半衰期为12h,生物利用度约为95.4%。结论该方法操作简单、准确可靠,可用于莫西沙星的临床药动学研究及临床特殊人群的血药浓度测定。
Objective To analyze the moxifloxacin hydrochloride in human body blood drug concentration and pharmacokinetic. Methods A single oral dose of moxifloxacin 400 mg was took by ten volunteers. We measured dynamic parameters of blood drug concentration and drug determination of Moxifloxacin Hydrochloride by solid phase extraction-high performance liquid chromatography method, used DAS2.0 software for automatic fitting, calculated of pharmacokinetic parameters. Results The pharmacokinetic parameters of moxifloxacin： t1/2a=（5.26±0.20）h;tl/2β-（7.80士0.50）h;AUC（-0）=（111.8±10.3）υg/（mL·h）;tmax=（3.13±0.32）h;Cmax=（13.5±0.42υg/mL; moxifloxacin in vivo drug concentration-time curves fitted to two compartment open model, in vivo elimination half-life was 12 h, the bioavailability was about 95.4%. Conclusion The method is simple, accurate and reliable, determination of drug concentration in blood and clinical study of special groups can be used in the clinical pharmacokinetics of moxifloxacin.
出处
《福建医药杂志》
CAS
2013年第3期68-71,共4页
Fujian Medical Journal
关键词
盐酸莫西沙星
固相萃取-高效液相色谱法
血药浓度
药动学
moxifloxacin hydroch!oride
solid phase extraction-high performance liquid chromatography
blood drug con-centration
pharmacokinetics
