摘要
目的研究急性脑梗死患者血浆同型半胱氨酸（Hcy）水平与颈动脉粥样硬化的关系，对其发病机制进行初步探讨。方法入选103例首次发病的急性脑梗死患者和46例健康体检者，应用颈动脉多普勒彩色超声检测颈动脉内膜中层厚度（IMT）。用免疫比浊法测定血浆Hcy，并对检测结果进行统计学分析。结果急性脑梗死组血浆Hcy水平明显高于对照组[（18．21±0．51）μmol／L比（12．32±0．16）μmol／L，P〈0．01]；脑梗死内膜增厚组、斑块组血浆Hcy明显高于无斑块组[（18．37±0．24）、（20．16±0．58）μmol／L比（13．25±0．13）μmol／L，P〈0．05]；斑块组血浆Hcy水平明显高于内膜增厚组（P〈0．05）。直线相关分析显示血浆Hcy水平与IMT呈正相关（r=0．68，P〈0．01）。结论血浆Hcy水平与急性脑梗死患者动脉粥样硬化程度密切相关，对高Hcy脑梗死患者进行干预是一种值得研究的防治手段。
Objective To investigate the relation between the serum homocysteine level in patients with a- cute cerebral infarction and carotid artery atheroselerosis. Methods In 103 patients with initial acute cerebral in- farction and 46 healthy persons, carotid intima-medial wall thickness（IMT） was determined with colored doppler ul- trasound; serum homocysteine level was determined with immnnoturbidimetry. Results The serum homoeysteine level in the patient group was significantly higher than that in control group[ （ 18.21 ±0.51 ） μmol/L vs （ 12.32 ± 0.16） μmol/L, P 〈 0.01 ]. The serum homocysteine level in the patients with carotid artery intima media thickness oratheromatous plaque was significantly higher than that in the patients without atheromatous plaque [ （ 18.37 ± 0.24 ）, （ 20.16 ± 0.58 ） μmol/L vs （ 13.25 ±0.13 ） μmol/L, P 〈 0.05 ]. The serum homocysteine level of patients with atheromatous plaque was significantly higher than that of patients with carotid artery intima media thickness（P 〈 0.05 ） ; the serum homocysteine level was positively correlated with intimal-medial wall thickness （ r = 0.68, P 〈 0.01 ）. Conclusion The serum homocysteine level is significantly correlated with the degree of atherosclerosis of patients with acute cerebral infarction.
出处
《中国医药》
2013年第7期917-918,共2页
China Medicine
基金
基金项目：南京市医学科技发展项目（课题）计划（YKK10180）
关键词
同型半胱氨酸
脑梗死
急性
颈动脉粥样硬化
Homocysteine
Cerebral infarction, acute
Carotid artery atherosclerosis
