摘要
目的探讨安理申治疗痴呆并发行为和精神症状(BPSD)的效果。方法 70例BPSD患者随机分为研究组和对照组各35例,均口服喹硫平治疗。研究组同时予安理申治疗。于治疗前后采用痴呆病理行为评定量表(BEHAVE-AD)及简易智能状态量表(MMSE)评定两组患者的痴呆程度及行为症状。结果治疗8周后,两组BAD评分均较治疗前有明显下降(P<0.01),两组间比较,研究组下降更明显(t=2.94,P<0.05)。两组MMSE评分较治疗前明显提高(P<0.05),两组间比较,研究组升高更明显(t=3.57,P<0.05)。结论安理申治疗BPSD患者,可有效控制患者的精神行为症状,改善其认知,提高其残存记忆功能。
Objective To explore the efficacy of Donepezil in treatment of dementia with behavioral and psychological symptoms（BPSD）.Methods A total of 70 patients with BPSD were randomly divided into study group（treated with combination of Donepezil and Quetiapine）and control group（treated with Quetiapine）for 8 weeks,and curative effectiveness was evaluated by using the BEHAVE-AD and MMSE.Results The BEHAVE-AD scores in two groups were significantly decreased after 8 weeks compared with those before treatment（P0.01）.However,reduction of BEHAVE-AD scores was more prominent in study group than in control group（t=2.94,P0.05）.The MMSE scores in two groups were significantly higher after 8 weeks compared with those before treatment（P0.05）.However,reduction of MMSE scores was higher in study group than in control group（t=3.57,P0.05）.Conclusion Donepezil combined with Quetiapine has better efficacy in the treatment of BPSD,and It can control in patients＇ behavioral and psychological symptoms and improve cognition and memory function.
出处
《中国健康心理学杂志》
2013年第6期815-816,共2页
China Journal of Health Psychology
关键词
精神卫生
安理申
痴呆
精神和行为症状
Mental hygiene
Donepezil
Dementia
Psychiatric and behavioral symptoms
