摘要
目的比较小剂量丙戊酸钠合并奥氮平与单用奥氮平治疗阿尔茨海默病精神行为症状的疗效。方法62例阿尔茨海默病患者随机分为联合用药组与单药组,双盲对照治疗2周,在治疗前、治疗第1周末、第2周末采用简明精神病评定量表(BPRS)进行评分并分析。结果第1周末,联合用药组总有效率为75%,与单药组(43.33%)之间的疗效差异有统计学意义(P<0.05)。第2周末2组之间的疗效差异无统计学意义(P>0.05)。BRPS评分比较,联合用药组在第1、2周末与治疗前比较差异均有统计学意义(P<0.05),而单药组在第2周末与治疗前比较差异有统计学意义(P<0.05)。结论小剂量丙戊酸钠合并奥氮平能更好、更快地控制阿尔茨海默病患者精神行为症状。
Objective To investigate the effect of combination therapy of small-dose sodium valproate and olanzapine on behavioral and psychological symptoms in patients with Alzheimer＇s disease. Methods Sixty-two patients with Alzheimer＇s disease were randomly divided into two groups, olanzapine group （single group） and sodium valproate combined with olanzapine group （ combination group） , receiving treatment for two weeks. The brief psychiatric rating scale （BPRS） was assessed before treatment, and at 1 st weekend and 2nd weekend. Results At the first weekend, the total effective rate was 75% in combination group, compared with 43.33 % in single group（P 〈 0. 05 ）, and at the second weekend, the significant difference was not found （P 〉 0. 05 ）. The scores of BPRS of combination group at the first and the second weekend were significantly lower than those before treatment（P 〈 0. 05 ） , but in the single group the significant difference was only found between the second weekend and before treatment （ P 〈 0.05 ）. Conclusions Small-dose sodium valproate combined with olanzapine are able to control the behavioral and psychological symptoms of Alzheimer＇s disease more quickly and effectively.
出处
《实用老年医学》
CAS
2009年第6期432-433,440,共3页
Practical Geriatrics
关键词
丙戊酸钠
奥氮平
阿尔茨海默病
行为症状
sodium valproate
olanzapine
Alzheimer＇s disease
behavioral symptoms
