摘要
目的:观察2∶1球浆比例换血疗法治疗新生患儿高胆红素血症的疗效及安全性。方法:将76例重症高胆红素血症需换血的新生儿随机分为两组,观察组40例采用2∶1球浆比例进行换血,对照组36例采用1∶1球浆比例进行换血。观察换血前后血胆红素、血常规、血电解质等指标变化。结果:观察组和对照组换血后血清总胆红素及直接胆红素均下降明显,总胆红素换出率约56%～57%,直接胆红素换出率在50%左右,迅速降低了总胆红素;观察组换血后RBC、HGB、K与换血前差异不大,对照组换血后RBC、HGB、K均下降较明显。结论:2∶1球浆比换血治疗重症高胆红素血症疗效明显,并预防贫血和电解质紊乱,疗效肯定,方法简单、实用、安全,值得推广。
Objective：Observe the efficacy and safety of exchange transfusion by using red blood cell vs. plasma of 2：1 for neonate hyperbilirubinemia. Methods： Retrospect 76 newborn infants of hyperbilirubinemia by using exchange transfusion with different propor- tions of red blood cell vs. plasma in department of neonatology from January 2004 to June 2012. The observation group included 40 ca- ses ,using red blood cell vs. plasma of 2 ：l in exchange transfusion. While the rate of control group of 36 cases is 1： 1. Observe the va- rious figures of hemobilirubin,blood routine examination and electrolyte before and after exchange transfusion. Results： The figures of serum total bilirubin and direct bilirubin decreased obviously both in the observation group and control group. The replacement rate of serum total bilirubin is about 56% ~ 57% , while the direct bilirubin is about 50% , which reduces the quantity of total bilirubin rapidly. Before and after exchange transfusion the RBC,HGB and K were similar in the observation group,but all of them decreased in the con- trol group after exchange transfusion. Conclusion： The efficacy of exchange transfusion of red blood cell vs. plasma 2：1 for neonate hyperbilirubinemia is clear and definite,which can also prevent anemia and electrolyte imbalance. The method has the advantages of simple, practical usage and high security, which is worthy of popularization.
出处
《川北医学院学报》
CAS
2013年第3期244-248,共5页
Journal of North Sichuan Medical College
基金
广州市医药卫生科技项目(2009-Zdi-26)
关键词
球浆比例
新生儿
换血疗法
高胆红素血症
Red blood cell vs. plasma
Newborn infant
Exchange transfusion
Hyperbilirubinemia
