摘要
目的:了解国家基本药物在使用过程中出现的药品不良反应/事件(ADR/ADE)的情况及对其原因进行分析,为临床合理用药提供参考,以减少或避免不良反应的发生。方法:对2011年1—9月收集到的304例由使用国家基本药物所产生的ADR/ADE报告进行统计和综合分析。结果:304例ADR/ADE报告中,男女比例为1∶1.1,其中<10岁患者分布最多(81例,占26.64%);共涉及54种药物,其中抗菌药物引起的ADR/ADE最为多见(224例,占73.68%),其次为中药制剂(32例,占10.53%);静脉用药引起的ADR/ADE为295例,占97.04%;ADR/ADE主要表现为皮肤及其附件损害(168例次,占总计378例次的46.34%)。严重的ADR/ADE为3例,新的ADR/ADE为77例。结论:ADR/ADE的报告和监测是医院进行药品监控和合理使用的重要环节,对国家基本药物致ADR/ADE进行监测,可以评价国家基本药物的安全性,为临床合理使用国家基本药物提供参考,以便更好地贯彻实施国家基本药物制度。
OBJECTIVE ：To analyze the status and the causes of the adverse drug reactions/events （ADR/ADE） during the use of national essential drugs for references of clinical rational use of drug and reduce or avoid the occurrence of ADR/ADE. METHODS： A total of 304 ADR/ADE cases induced by national essential drugs collected during Jan. - Sep. period of 2011 were analyzed statistically. RESULTS： Of the 304 ADR/ADE cases, the ratio of males to females was 1：1.1, with patients aged 〈 10 topping the list （81 cases, accounting 26. 64% ）. A total of 54 kinds of drugs were involved, with antibu topping the list in terms of number of ADR/ADE cases [224 cases （73.68%） ], followed by the traditional Chinese medicine [32 cases （10. 53% ） ]. 295 cases （97.04%） were induced intravenously. The ADR/ADE appeared mainly as skin and appendages disorders, accounting for 46. 34% （168/378）. There were three serious ADR cases and seventy-seven new ADR cases. CONCLUSION： The monitoring and reporting of ADR/ADE is an important link in monitoring and rational use of drugs in hospital. Monitoring of national essential drugs-induced ADR/ADE pave the way to the evaluation of the safety of national essential drugs so as to provide reference for rational use of drugs in clinic and facilitate the implementation of national essential drugs system.
出处
《中国医院用药评价与分析》
2013年第5期464-466,共3页
Evaluation and Analysis of Drug-use in Hospitals of China
关键词
药品不良反应
事件
国家基本药物
合理用药
安全性
Adverse drug reactions/events
National essential drugs
Rational use of drug
Safety
