摘要
目的探讨妊娠期肝内胆汁淤积症(ICP)患者肝功能及胎儿左心室Tei指数变化,分析胎儿猝死原因。方法分别选取ICP患者40人,正常孕妇40人,测量母体血总胆汁酸,总胆红素,丙氨酸氨基转移酶值,应用多普勒超声心动图测定胎儿左心室Tei指数。结果 ICP组血总胆汁酸,丙氨酸氨基转移酶水平较正常组升高,差异有统计学意义(P<0.05);两组比较,血总胆红素差异无统计学意义(P>0.05);ICP组与正常组胎儿左心室Tei指数比较,差异无统计学意义(P>0.05)。结论血清总胆汁酸,丙氨酸氨基转移酶是诊断ICP的敏感指标,ICP患者胎儿在晚孕左心室Tei指数没有明显变化。
Objective To investigate the changes of liver fimction in patiems with intrahepatic cholestasis of pregnancy （ICP） and fetal Tei index, to analyze the cause of fetal sudden death. Methods Forty cases of patients with intrahepatic cholestasis of pregnancy were selected, and forty cases of normal pregnancy women were regarded as control. We detected the levels of maternal total serum bile acid, total bilirubin and alanine aminotransferase in the two groups. Fetal left ventricular Tei index in the two groups was evaluated by Doppler echocardiography. Results The maternal total serum bile acid and alanine aminotransferase levels in the ICP group were higher than those in the control group, with significant statistical difference （P 〈0.05）. The results for serum total bilirubin and fetal left ventricular Tel index in the two groups showed no statistical difference （P 〉0.05）. Conclusions Total serum bile acid and alanine aminotransferase levels are sensitive marks to diagnose intrahepatic cholestasis of pregnancy. No significant change is found in fetal left ventricular Tei index in patients with intrahepatic cholestasis of late pregnancy.
出处
《临床医学工程》
2013年第6期662-663,共2页
Clinical Medicine & Engineering
