摘要
目的考察注射用头孢西丁钠与茵栀黄注射液在5%葡萄糖注射液中的配伍稳定性。方法采用高效液相色谱法(HPLC)测定头孢西丁钠与茵栀黄注射液配伍后4h内头孢西丁和黄芩苷,并考察配伍后外观、pH值及不溶性微粒的变化。结果配伍后的液体在4h内的外观、pH值无明显改变,但不溶性微粒数逐渐增多,二者的含量均逐渐降低。结论头孢西丁钠与茵栀黄注射液配伍后4h内不稳定,不建议临床配伍使用。
Objective To investigate the compatible stability of cefoxintin sodium for injection and Yinzhihuang Injection（a compound injection of Chinese materia medica） in 5% glucose injection.Methods high performance liquid chromatography（HPLC） was established for the quantitative determination of cefoxintin and baicalin within 4 h after the compatibility of cefoxintin sodium for injection and Yinzhihuang Injection,and the changes of solution color,pH value,and insoluble particles were observed.Results The solution color and pH value showed no obvious changes.But the contents of cefoxintin and baicalin as well as the insoluble particles were increased with the compatible time extending.Conclusion The solution is unstable within 4 h after the compatibility of cefoxintin sodium for injection and Yinzhihuang Injection.So it should not be used in the compatibility.
出处
《现代药物与临床》
CAS
2013年第3期385-388,共4页
Drugs & Clinic
