摘要
目的探讨大剂量泼尼松口服冲击治疗儿童免疫性血小板减少症（1TP）的疗效。方法根据治疗方法不同，将患儿分为泼尼松冲击组、丙种球蛋白冲击组及甲泼尼龙冲击组。记录3组患儿治疗第5天及第30天外周血血小板水平，并记录冲击治疗期间患儿血压水平。采用∥检验比较其有效率及高血压的发生率有无统计学差异。结果新诊断Ⅱ＇P患儿中，泼尼松冲击组患儿第5天有效率与丙种球蛋白冲击组及甲泼尼龙冲击组比较差异无统计学意义（P〉0．05）。泼尼松冲击组第30天有效率较丙种球蛋白冲击组显著升高（P〈0．05），与甲泼尼龙冲击组比较差异无统计学意义（P〉0．05）。持续性及慢性ITP患儿中，泼尼松冲击组第5天及第30天有效率较丙种球蛋白冲击组显著升高（P〈0．05），与甲泼尼龙冲击组相比差异无统计学意义（P〉0．05）。泼尼松冲击组患儿高血压发生率较甲泼尼龙冲击组显著降低（P〈0．05）。结论大剂量泼尼松口服冲击治疗儿童ITP安全、有效。
Objective To explore curative effects of high-dose prednisone used for children with immune thromboeytopenia （ITP）. Methods The children with ITP were divided into prednisone group, γ-globulin group and methylprednisolone group. Platelet levels in peripheral blood were recorded after treatments within the 5th day and the 30m day, and the blood pressure levels of children were also recorded during treatments. The X2 test was used to compare the effective rate of different treatments as well as the incidence rate of hypertension in these 3 groups. Results In new diagnosis children,there was no significant difference in the effective rate among the 3 groups in the 5th day（P 〉 0.05 ）. The effective rate of prednisone group in the 30th day was significantly higher than γ-globulin group （ P 〈 0.05 ）, and there was no significant difference than methylprednisolone group （ P 〉 0.05 ）. In persistence and chronic ITP children,the effective rate of prednisone group were both significantly higher than those in γ-globulin group in the 5th days and the 30th day （P 〈0.05 ）,and were also no significantly higher than those in methylprednisolone group （P 〉 0. 05 ）. The incidence rate of hypertension was significantly lower in prednisone group than that in methylpredlfisolone group （P 〈0. 05 ）. Conclusion High-dose prednisone oral treatment is safe, effective and worth using in children with ITP.
出处
《中华实用儿科临床杂志》
CAS
CSCD
北大核心
2013年第9期712-714,共3页
Chinese Journal of Applied Clinical Pediatrics
