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病毒感染与免疫性血小板减少性紫癜的关系 被引量:10

Correlation between Virus Infection and Immune Thrombocytopenic Purpura in Children
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摘要 目的探讨免疫性血小板减少性紫癜(ITP)与病毒感染的关系。方法回顾性分析60例儿童ITP的临床资料,采用ELISA法检测60例ITP患儿血清病毒抗体,包括EB病毒(EBV)及巨细胞病毒(CMV)等,比较病毒抗体检测在病毒感染组及非病毒感染组ITP患儿中的临床特点及治疗效果。结果病毒血清学检测:病毒感染36例,非病毒感染24例。病毒感染组与非病毒感染组比较:(1)皮肤黏膜出血点及瘀斑例数、鼻出血例数及消化道出血例数比较差异均无统计学意义(Pa>0.05)。(2)2组Hb及血小板计数比较差别均无统计学意义(Pa>0.05)。(3)治疗2个月效果比较差异有统计学意义(P<0.05),病毒感染组初始疗效较非病毒感染组治疗有效率低。(4)治疗6个月2组疗效比较差异有统计学意义(P<0.05),治疗6个月病毒感染组无效13例,39.4%呈慢性倾向,明显高于非病毒感染组(10.0%)。结论多数ITP患儿伴有病毒感染;病毒感染相关的ITP疗效较非病毒感染的ITP疗效差,导致病程迁延。对并病毒感染的ITP患儿应进行抗病毒治疗。
出处 《实用儿科临床杂志》 CAS CSCD 北大核心 2011年第21期1687-1688,共2页 Journal of Applied Clinical Pediatrics
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