摘要
目的观察托吡酯治疗抗精神病药奥氮平所致体重增加的疗效与安全性。方法选取我院住院治疗的精神分裂症患者60例,分为观察组和对照组各30例。对照组在奥氮平治疗基础上使用安慰片治疗,观察组在奥氮平治疗基础上采用托吡酯治疗,比较两组疗效。结果观察组患者治疗8周后身体各项指标体重、BMI、腰围、臀围及WHR均明显低于对照组(P均<0.05);其余指标组间均无显著性差异,两组患者治疗后BPRS评分均有明显下降,观察组下降明显高于对照组。结论常规奥氮平治疗联合托吡酯对精神分裂症患者进行治疗,能够减轻体重增加的副反应,为治疗抗精神病药所致体重增加提供新的临床手段。
Objective To observe the effects and safety of topiramate treatment in weight gain caused by olanzapine of antipsychotics. Methods Sixty patients with schizophrenia symptoms in our hospital were divided into two groups （ob- servation group and control group）： In the control group on the basis of olanzapine treatment using comfort treatment, observation group based on olanzapine treatment using topiramate treatment; compare two groups of patients with cu- rative effect. Results The observation group of patients after treatment for 8 weeks the indicators weight, BMI,waist circumference,hip circumference and WHR were significantly lower than control group （ p all 〈 0.05）;the rest of the indicators are no significant differences between groups. Conclusion conventional olanzapine treatment combined with topiramate treatment in patients with symptoms of schizophrenia,can mitigate the side effects of w,~i,~h~ ,o; ：_L. gain associated w;th o,~; L-~： .
出处
《中国现代医生》
2013年第17期78-80,共3页
China Modern Doctor
基金
浙江省医学会临床科研基金项目(2011ZYC-A70)
