摘要
目的:研究枸骨Ilex cornuta Lindl.et Paxt.根的化学成分。方法:利用硅胶柱色谱法、Sephadex LH-20凝胶柱色谱法、中压柱层析及半制备高效液相色谱等方法分离纯化;通过核磁共振谱、质谱等光谱数据鉴定化合物结构。结果:分离鉴定了10个化合物,分别为:齐墩果酸(1)、暹罗树脂酸(2)、19α-羟基-乌苏酸-28-O-β-D-吡喃葡萄糖苷(3)、坡模酸(4)、23-羟基-坡模酸-3β-O-α-L-吡喃阿拉伯糖苷(5)、19α-羟基-齐墩果酸-3β-O-α-L-吡喃阿拉伯糖基-28-O-β-D-吡喃葡萄糖苷(6)、23-羟基-羽扇豆醇(7)、竹节参皂苷Ⅳa正丁酯(8)、齐墩果酸-3β-O-β-D-吡喃葡萄糖醛酸甲酯苷(9)、齐墩果酸-3β-O-[α-L-吡喃阿拉伯糖基(1→2)]-β-D-吡喃葡萄糖醛酸甲酯苷(10)。结论:其中,化合物7～10为首次从该属植物中分离得到,化合物2～6为首次从该植物中分离得到。
Objective：To investigate the chemical constituents of the root of Ilex cornuta.Methods：The constituents were isolated by silica gel,Sephadex LH-20 gel,medium pressure column and semi-preparative liquid chromatography and their structures were elucidated by chemical properties and spectroscopic analyses.Results： Ten compounds were isolated and their structures were identified as：Oleanolic acid（1）,Siaresinolic acid（2）,28-O-β-D-glucopyranosyl pomolic acid（3）,Pomolic acid（4）,3β-O-α-L-arabinopyranosyl rotundic acid（5）,3β-[α-L-arabinopyranosyl）oxy]-19α-hydroxyolean-12-en-28-oic acid 28-β-D-glucopyranosyl ester（6）,Lup-20（29）-en-3β,23-diol（7）,Chikusetsusaponin Ⅳa butyl ester（8）,Oleanolic acid-3-O-（6′-O-methyl）-β-D-glucuronopyranoside（9）,3-O-[（α-L-arabinopyranosyl）-（12）]-β-D-glucuronopyranosyl-（6′-O-methyl-ester）-olean-12-ene-28-olic acid（10）.Conclusion：Compounds 7~10 are isolated from this genus for the first time,and compounds 2~6 are isolated from this plant for the first time.
出处
《中药材》
CAS
CSCD
北大核心
2013年第2期233-236,共4页
Journal of Chinese Medicinal Materials
关键词
枸骨
根
化学成分
分离鉴定
Ilex cornuta Lindl.et Paxt.
Root
Chemical constituents
Isolation and identification
