摘要
目的探讨俄色总黄酮(Total Flavonoids from E’se,ES)对糖尿病(Diabetes Mellitus,DM)小鼠的治疗作用。方法建立链脲佐菌素(Streptozotocin,STZ)致DM小鼠模型,灌胃ES 180、90、45 mg/kg连续7 d。结果试验后测得DM小鼠体重减轻,血糖升高,肝及脾肿大、胸腺萎缩的症状得以缓解,肝糖原含量有一定程度的降低、血清胰岛素含量有一定程度的升高。结论ES能改善DM小鼠一般状态,明显降低肝脏和脾脏系数,有调节血糖、肝糖原合成和血清胰岛素分泌作用趋势,具有治疗DM的作用。
Objective To observe pharmacological effects of ES on DM mice. Methods First,we establish the DM mice model that is caused by STZ, and then give a gavage of ES of the quality of 180 90 45 mg/kg to corresponding group mice respectively for continuous 7 d. Results After test,we have measured DM mice weight loss, high blood sugar, liver and spleen enlargement, thymic atrophy symptoms to relief, the content of hepatic glycogen of a certain degree of loss, serum insulin content increased to a certain extent. Conclusion ES can improve general state of DM mice, decrease the liver and spleen coefficient.At the same time ,it has a trend of regulating their blood glucose and hepatic glycogen synthesis and serum insulin secretion, and it has therapeutic effects on DM.
出处
《中外医疗》
2013年第14期25-27,共3页
China & Foreign Medical Treatment
基金
四川成都中医药大学大学生创新性实验项目(2011CXXMYB03)
关键词
糖尿病
俄色总黄酮
链脲佐菌素
Diabetes mellitus （DM）
Total flavonoids from E＇se （ES）
Streptozotocin （STZ）
