摘要
目的:探讨重组人促卵泡激素(rhFSH)低剂量递增方案联合宫腔内人工授精(IUI)临床效果及卵巢反应预测因子。方法:选择多囊卵巢综合征、WHO II型排卵障碍及不明原因不孕患者60例,采用rhFSH(果纳芬)低剂量递增方案促排卵联合IUI,分析妊娠率、多胎妊娠率、卵巢过度刺激综合征(OHSS)发生率,并对卵巢反应预测因子加以分析。结果:①临床妊娠率28.21%,双胎妊娠率9.09%,流产率18.18%,促排卵过程中发生OHSS(轻度)1例,无三胎及以上妊娠。②促排卵成功患者与卵巢反应不良患者在体质量、体质量指数(BMI)、窦卵泡数(AFC)、rhFSH总剂量比较,差异均有统计学意义(P<0.05)。结论:rhFSH低剂量递增方案可以使排卵障碍特别是对其他促排卵药物抵抗患者获得较好的妊娠结局,促排卵结局可能受患者体质量、BMI、AFC等因素影响。
Objective： To identify baseline predictors of ovarian responses and pregnancy outcomes in patients who received intrauterine insemination（IUI） combined with recombinant human FSH（rhFSH） low-dose step-up protocols.Methods： The clinical outcomes were analysed in IUI cycles with rhFSH low-dose step-up protocols to identify baseline predictors of ovarian responses.Results： 1） The pregnancy rates,twins rates and abortion rates were 28.21%,9.09% and 18.18%,respectively.Only one OHSS case happened and there was no multiple pregnancy in all cases.2） There was a statistically significant difference in weight,body mass index（BMI）,antral follicle count（AFC） and gonadotrophin used amount between IUI and poor response groups.Conclusion： The pregnancy outcomes of IUI treatment with rhFSH low-dose step-up protocols is better for the anovulatory women who are resistant to other therapy and may be affected by prediction parameters,including weight,BMI,AFC,etc.
出处
《生殖与避孕》
CAS
CSCD
2013年第5期343-346,共4页
Reproduction and Contraception
基金
江苏省科委临床医学科技专项(BL2012009)
卫生行业科研专项(201002013)资助
