摘要
采用静电纺技术,制备了纯聚乙烯醇(PVA)和担载了不同量抗凝血药物低分子右旋糖酐(Dex-40)的载药纳米纤维膜,研究了药量对膜血液相容性的影响。借助扫描电镜(SEM)和傅里叶红外光谱仪(FT-IR)观察纤维形貌、分析膜的组分;用电子万能强力仪测试了膜的力学性能;以溶血、动态凝血实验研究了药物和药量对膜血液相容性的影响。结果表明:可纺性较好的纺丝液浓度为PVA10%、药粉1%,PVA和药粉能很好地融合在一起,载药膜的拉伸强度稍高于纯PVA膜,但断裂伸长率有所下降。添加药粉后,载药膜的溶血率低于5%,且内源性凝血因子被激活的程度低,膜的血液相容性显著改善。
To manufacture pure polyvinyl alcohol（PVA） and drug-loaded nanofiber film which carried different a- mount of anticlotting drug low molecular dextran（Dex-40） via electrospinning. The effect of amount of drug on the bicom- patibility of electrospun nanofiber film was studied. The films were charaterized by scanning electron microscopy（SEM） and Fourier transform infrared spectroscopy （FT-IR）, the mechanical propety was tested by the electronic universal strength tester. The effect of drug and amount of drug on the biocompatibility of electrospun nanofiber film were studied through hemolysis test and blood coagulation test（. The results showed that the concentration of solution which had electrospun well was PVA10 % and drug1%, PVA and drug mixed well, the tensile strength of drug-loaded films were slightly higher than pure PVA films, but elongation at break were declined accordingly. The addtion of drug made the hemolysis rate of drug- loaded films were less than 5 %, and the activated level of endogenous clotting were low, the blood compatibility of film got a good improvement.
出处
《化工新型材料》
CAS
CSCD
北大核心
2013年第5期49-51,57,共4页
New Chemical Materials
基金
教育部长江学者和创新团队发展计划(IRT1135)
江苏高校优势学科建设工程资助项目
