摘要
目的观察中药加味逍遥散治疗面部黄褐斑患者的临床疗效,分析治疗前后血清性激素水平变化情况。方法观察组采用加味逍遥散加减治疗,1个月为1疗程,轻症患者1～2个疗程,中重症患者3～5个疗程。对照组采用维生素C每次0.3 g,3次/d,外擦3%氢醌霜或迪维霜于色斑处,2次/d;观察组患者治疗前后于月经前1周抽取空腹静脉血,检测其促卵泡生成素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)的含量。观察两组临床疗效,分析血清性激素水平变化。结果 (1)观察2组总有效率为93.33%;对照组总有效率为55.00%。两组比较差异有统计学意义(P<0.05)。(2)黄褐斑患者血清FSH、LH、E2治疗前后比较,差异有显著统汁学意义(P<0.01);血清P与治疗前比较,差异无统计学意义(P>0.05)。结论采用加味逍遥散辨证论治黄褐斑疗效显著,且对患者性激素水平有调节作用。
Objective To observe the clinical efficacy for main recipe Xiaoyaosan in the treatment of facial melasma. The changes of serum sex hormone levels before and after treatment were taken for analysis. Methods The observation group was taken with the modified Xiaoyaosan for treatment. One month was set as a course, and the mild patients were taken for 1 to 2 courses. The severe patients were taken for 3 to 5 courses. The control group was taken with vitamin C, each was with 0.3g, 3 times a day, and outside rub 3% hydroquinone cream or tretinoin cream stain 2 times a day. Blood samples before and after treatment one week before menstruation for the observation group were siphoned. The content of FSH（promoting d bubble-stimulating hormone）, LH（luteal EPO）, E2（estradiol）, （progesterone） levels were detected. The clinical efficacy of the two groups was observed, and the changes in serum sex hormone levels were taken for analysis. Results （1） The total effective rate of the observation group was 93.33%, and the total effective rate of the control group was 55.00%. Compare between the two groups, there were significant difference （P〈0.05） . （2）The cinnamon classes of serum FSH, LH, E： before and after treatment were compared, the difference was with statistical significance,（P〈0.01）and the difference was not statistical significant in serum P than before treatment, （P〉 0.05）. Conclusion The efficacy of modified Xiaoyaosan in the treating of melasma is significant, and it has the regulatory role of the sex hormone levels.
出处
《湖南中医药大学学报》
CAS
2013年第4期71-72,共2页
Journal of Hunan University of Chinese Medicine
关键词
加味逍遥散
黄褐斑
中医辨证论治
临床观察
The flavoredXiaoyaosan
Chloasma
Chinese medicine dialectical theory of governance
