摘要
目的:研究健骨活血丸对骨性关节炎模型兔关节液和血清中TNF-α表达的影响。方法:采用Hulth造模法建立OA模型,造模后肌注青霉素1周,预防感染,4周后灌胃,6周后取关节液和血清,测定TNF-α水平。结果:中药组关节液和血清中TNF-α明显低于对照组,差异有统计学意义,(P<0.01)。结论:中药健骨活血丸对骨性关节炎兔关节液和血清中TNF-α表达有明显的抑制作用,对骨性关节炎有良好的治疗作用。
Objective：To study the effect of ＂Jianguhuoxue Pill＂ on TNF-a in serum and synovial fluid in rabbits with osteo- arthritis. Methods： After OA model were made by Hulth＇s method, the rabbits received intramuscular injection of penicillin to prevent infection for 1 week. Medication via gastrogavage was given 4 weeks later. The TNF-α level in serum and syno- vial fluid was detected 6 weeks after the model was established. Results：The TNF-α level of serum and synovial fluid in model group was obviously lower than that in control group. The difference was significant （P〈0.01）. Conelusion：Jiangu- huoxue Pill can significantly inhibit the expressions of TNF-α in serum and synovial fluid in rabbits with osteoarthritis, and it has obvious therapeutic effect on osteoarthritis.
出处
《中国中医骨伤科杂志》
CAS
2013年第5期12-14,共3页
Chinese Journal of Traditional Medical Traumatology & Orthopedics
基金
抚顺市科技攻关课题
