摘要
目的通过横断面研究观察我国中老年女性血尿酸(SUA)水平和心律失常风险的关系。方法以2007～2008年我国糖尿病和代谢异常研究数据库中,同时具备SUA和心电图明尼苏达码>50岁的女性为研究对象,按SUA水平分为低、中、高3组。以OR值和Meta分析比较心律失常风险在组间的统计学差异。以Logistic回归和Meta分析校正其他心血管事件危险因素后,比较心律失常风险在不同组间的统计学差异。结果共2172例纳入分析,高尿酸(HSUA)组心律失常风险高于中尿酸(MSUA)组(OR:1.98,95%CI:1.12～3.50)和低尿酸(LSUA)组(OR:1.73,95%CI:1.11～2.71)。校正其他心血管事件危险因素后,HSUA组心律失常风险仍高于MSUA组(校正后OR:2.36,95%CI:1.26～4.39)和LSUA组(校正后OR:1.80,95%CI:1.11～2.90)。MSUA组和LSUA组心律失常风险比较差异无统计学意义(OR:0.84,95%CI:0.55～1.30)。结论高尿酸血症(HUA)与我国中老年女性心律失常独立相关,SUA升高是我国中老年女性危险因素之一。
Objective To investigate the association between serum uric acid （SUA） and the risk for arrhythmia in middle- and old-aged women in China by a cross-sectional survey. Methods Women with SUA and Minnesota code of electrocardiogram （ECG）, aged above 50 years, were chosen to be study population. The study population was split into three groups： low SUA group, middle SUA group, and high SUA group. OR and Meta-analysis were used to compare arrhythmia risk between SUA groups. Logistic regression and Meta-analysis were applied to compare arrhythmia risk after adjusting for other risk factors of cardiovascular disease （CVD） between SUA groups. Results A total of 2172 people were enrolled in the study. Individuals in the high SUA group had higher arrhythmia risk than those in the middle SUA group （OR： 1.98, 95%CI： 1.12～3.50） and in the low SUA group （OR： 1.73, 95%CI： 1.11～2.71）. After adjusting for other CVD risk factors, individuals in the high SUA group still had higher arrhythmia risk than those in the middle SUA group （adjusted OR： 2.36, 95%CI： 1.26～4.39） and in the low SUA group （adjusted OR： 1.80, 95%CI： 1.11～2.90）. There was no significant difference in arrhythmia risk in comparing the middle SUA group with the low SUA group （OR： 0.84, 95%CI： 0.55～1.30）. Conclusion High SUA level is independently related to arrhythmia in women aged above 50 years in China. Arrhythmia risk will rise when SUA rises.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2013年第5期402-406,共5页
Chinese Journal of Diabetes
关键词
中老年女性
血尿酸
心律失常
Middle- and old-aged women
Serum uric acid （SUA ）
Arrhythmia
