摘要
目的 探讨钙敏感受体在甲状腺乳头状癌、甲状腺良性肿瘤、正常甲状腺组织中的表达特点，分析其与甲状腺乳头状癌的的关系。方法 甲状腺手术后标本70例（甲状腺乳头状癌组织40例、甲状腺良性肿瘤20例、甲状腺正常组织10例），应用MaxvisionTM2/HRP免疫组化二步法染色对甲状腺乳头状癌组织、甲状腺良性肿瘤及甲状腺正常组织的钙敏感受体进行检测。所有资料均采用SPSS 17.0进行统计分析，采用非参数检验，P〈0.05为差异有统计学意义。结果 钙敏感受体在甲状腺乳头状癌与甲状腺良性肿瘤、甲状腺正常组织间的表达差异有统计学意义（分别为90%,40%,0%;P〈0.05）。甲状腺乳头状癌钙化组中钙敏感受体的阳性表达高于甲状腺癌无钙化组，且高于甲状腺良性肿瘤钙化组，差异有统计学意义（P〈0.05）。结论 钙敏感受体与甲状腺乳头状癌有着密切的关系。钙敏感受体可能在甲状腺乳头状癌组织的钙化起到重要作用。
Objective To explore the relationship between calcium-sensing receptor′s expression and papillary thyroid carcinoma. Methods Seventy cases of postoperative papillary thyroid carcinoma were selected. Immunohistochemical technique was used to detect expression of calcium-sensing receptor in papillary thyroid carcinoma, thyroid benign lesions, and normal thyroid tissue, respectively. SPSS 17.0 statistical analysis was used with non parametric test, P〈0.05 indicated significant difference. Results The expression of calcium-sensing receptor in papillary thyroid carcinoma, benign thyroid, and normal thyroid were significantly different（90%,40%,0%, respectively; P〈0.05）.The expression of the calcium-sensing receptor in the group of papillary thyroid carcinoma with calcification was significantly higher than that in thyroid cancer without calcification（P〈0.05）. Conclusions This study suggests that the calcium-sensing receptor may be associated with papillary thyroid carcinoma and may play a key role in the calcification of the carcinoma.
出处
《中华内分泌代谢杂志》
CAS
CSCD
北大核心
2013年第4期293-296,共4页
Chinese Journal of Endocrinology and Metabolism
关键词
钙敏感受体
甲状腺乳头状癌
钙化
免疫组化
Calcium-sensing receptor
Papillary thyroid carcinoma
Calcification
Immunohistochemical
