摘要
背景5-羟色胺3（5-HT3）受体拮抗剂特别是第2代5-HT3受体拮抗剂帕洛诺司琼对术后恶心呕吐（postoperativenauseaandvomiting，PONV）具有较好的预防作用，其药理学机制及临床应用状况近年来有了较为深入的研究和临床应用。目的分析总结帕洛诺对各类手术PONV的预防效果及其作用机制。内容第2代5-H％受体拮抗剂帕洛诺司琼具有高度亲和性、长效性、副作用少等优点，通过阻断5-H％与外周或中枢神经元的5-HT3受体结合，阻断迷走神经传人呕吐中枢和第四脑室化学感受区触发带，抑制呕吐反射，临床应用其预防PONV的高效性不断得到认可。趋向深入探讨其药理机制、副作用、预防PONV的临床应用等方面，以供临床工作者更加合理地应用其预防PONV。
Background The 5-HT3 antagonist, especially the second-generation of 5-HT3 antagonist palonosetron shows better efficacy against postoperative nausea and vomiting （PONV）, its pharmacological mechanism and clinical efficacy were further investigated. Objective This paper sums up litures on its pharmacological mechanism and clinical efficacy on PONV prophylaxis. Content The second-generation 5-HT3 antagonist palonosetron has properties of greater receptor affinity, prolonged duration of action and few adverse effects. It blocks serotonin binding at vagal afferents in the gut and in the regions of the CNS involved in emesis, including the chemoreceptor trigger zone and the nucleus tractus solitarii, inhibits and emesis reflex, the high efficacy of palonosetron is being recognized. Trend This review summarizes its pharmacological mechanism of action, adverse effects, and clinical application on prevention of PONV, offering clinical reference to clinician to prevent PONV more reasonably.
出处
《国际麻醉学与复苏杂志》
CAS
2013年第5期441-443,460,共4页
International Journal of Anesthesiology and Resuscitation
关键词
帕洛诺司琼
术后恶心呕吐
Palonosetron
Postoperative nausea and vomiting
