摘要
目的:评价小剂量氟哌利多预防腹腔镜下胆囊切除手术后恶心呕吐(PONV)的效果。方法:90例ASAⅠ～Ⅱ级择期腹腔镜下胆囊切除患者,随机分成恩丹西酮4mg组(对照组),氟哌利多10μg/kg组(实验组),每组45例。观察术后24h内各组患者恶心呕吐的发生率情况。结果:氟哌利多组和恩丹西酮组术后24h内恶心发生率分别是26.7%和31.1%,呕吐发生率是20.0%和15.6%,差异无统计学意义(P>0.05)。24h内两组均未观察到焦虑、锥体外系反应、Q-T间期延长等副反应的发生。结论:小剂量氟哌利多预防PONV和恩丹西酮一样有效。
Objective： To investigate the preventive effect of small-dose Droperidol against postoperative nausea and vomiting （PONV） after laparoscopic cholecystetomy. Methods： Ninety ASA Ⅰ or Ⅱ patients were randomly divided into Ondansetron （4 mg, IV） group and Droperidol （10 txg/kg, Ⅳ） group, with 45 patients in each group. Nausea and vomiting were observed during 24 hours of post operation. Results： No significant differences were observed in the terms of incidence rate of postoperative nausea between Ondansetron group （26.7 %）and Droperidol group （31.1%）, and so did postoperative nausea incidences（20.0%, 15.6%） （P〉0.05）. No remarked adverse effects were observed within 24 hours of postoperatively. Conclusion： Intravenous Ondansetron （4 mg） or Droperidol （10 ug/kg） can prevent PONV with similar efficacy and safety.
出处
《中国医药导报》
CAS
2008年第32期33-34,共2页
China Medical Herald
关键词
氟哌利多
小剂量
腹腔镜手术
术后恶心呕吐
预防
Droperidol
Small-Dose
Laparoscopic operation
Post-operative nausea and vomiting
Prevent
