摘要
目的探讨恶性肿瘤患者并发真菌感染的病原菌分布特点,了解其耐药现状,为临床合理选用抗菌药物、控制医院感染提供依据。方法对3 292例医院真菌感染的恶性肿瘤患者临床资料进行回顾性调查分析,真菌培养、鉴定和药敏试验严格按照《全国临床检验操作规程》及试剂说明书进行。结果 3 292例真菌感染中感染部位以呼吸道为主,占57.29%,其次为泌尿道、消化道、血液等;引起感染的真菌主要是白假丝酵母菌占89.06%,其次为光滑假丝酵母菌占5.98%;分离出的菌株对所试药物两性霉素B、氟胞嘧啶的耐药率均为0.00%,对伏立康唑、氟康唑和伊曲康唑的耐药率相对偏高。结论必须加强医院感染管理,控制易感因素,加强对真菌的耐药性监测,根据药敏试验结果规范合理使用抗真菌药物。
Objective To investigate the distribution characteristics and drug resistances of the pathogens of fungal infection in malignant tumor patients and provide evidences for clinical rational use of antibiotics and control of nosocomial infection.Methods The clinical data of 3,292 malignant tumor patients with nosocomial fungal infections were analyzed retrospectively.Fungi cultivation,identification and susceptibility tests were performed strictly in accordance to the National Guide to Clincal Laboratory Procedures and the instructions of use of the reagents.Results In the 3,292 patients with fungal infection,respiratory tract was the main fungal infection site,accounting for 57.29%,followed by the urinary tract,gastrointestinal tract and blood.The fungal infections were caused mainly by Candida albicans(89.06%),then Candida glabrate(5.98%).Drug resistance rates of the isolated strains to amphotericin B and fluorocytosine were both 0.00%,while those to voriconazole,fluconazole and itraconazole were relatively high.Conclusion It is necessary to strengthen the management of nosocomial infection and monitoring of fungus drug resistance,control the predisposing factors as well as use antifungal drugs rationally according to the results of drug sensitivity test.
出处
《中国微生态学杂志》
CAS
CSCD
2013年第4期452-453,456,共3页
Chinese Journal of Microecology
关键词
恶性肿瘤
真菌感染
耐药性
Malignant tumor
Fungal infection
Drug resistance
