摘要
合成了结构可切换型甲基丙烯酸酯季铵盐(CBMA-1C2).在聚丙烯(PP)片基表面光接枝构建CBMA-1C2聚合物刷,其在碱性水溶液中可水解形成两性离子聚合物刷PCBMA.用蛋白质吸附及血小板黏附实验评价改性表面亲/疏水性及表面电荷对生物分子与材料表面之间相互作用的影响.结果发现,与未改性PP片基相比,聚合物PCBMA-1C2改性表面水解前后均具有优异的亲水性能,由于聚合物PCBMA-1C2水解前后表面电荷不同,对生物分子与改性PP表面的相互作用表现出明显差异.亲水性好、两性离子结构的聚合物PCBMA表面表现出对蛋白吸附和血小板黏附的良好抑制作用.
A structure-switchable monomer N, N-dimethyl-N- （ ethoxycarbonylmethyl ） -N- [ 2＇- （ methacryloyloxy） ethyl] ammoniumbromide （ CBMA-1 C2） was synthesized. The polymer brush of PCBMA-1 C2 was fabricated on the polypropylene（PP） surface by photografting polymerization method, which could be hydrolyzed in alkaline aqueous solution to produce the polymer brush PCBMA surface （PP-PCBMA） with zwitterionic structure. The attenuated total reflectance infrared （ATR-IR） spectroscopy and X-ray photoelectron spectroscopy （XPS） were used to characterize the modified PP surface. The hydrophilia/hydrophobicity of PP before and after photografting and hydrolysis were measured by static contact angle measurements. The uniformity of surface elemental composition was monitored by dynamic contact angle measurements. The effect of hydrophilicity/hydrophobicity and charge types of the surface on the interactions between biological molecules and material surface were assessed by protein adsorption and platelet adhesion experiment. The results show that the PPPCBMA-1C2 and PP-PCBMA have good hydrophilic properties. However, the difference in surface charge types made their protein adsorption and platelet adhesion behavior greatly different. The results suggested that the PP surface with good hydrophilicity and zwitterionic structure exhibited strong resistance of protein adsorption and platelet adhesion.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第5期1270-1276,共7页
Chemical Journal of Chinese Universities
基金
国家自然科学基金(批准号:21004047)
陕西省教育厅专项科研计划(批准号:09JK767)
陕西省自然科学基础研究计划(批准号:2010JQ2004)
中国博士后科学基金(批准号:20100471629
201104673)资助
关键词
光接枝
聚合物刷
表面改性
蛋白质吸附
血小板黏附
Photografting
Polymer brush
Surface modification
Protein adsorption
Platelet adhesion
