摘要
目的:研究龙利叶水提液的抗炎和镇痛作用。方法:采用改良寇氏法对其急性毒性进行研究;采用二甲苯致小鼠耳廓肿胀、角叉菜胶致大鼠足跖肿胀、小鼠棉球肉芽肿增生模型,评价龙利叶水提液(含生药14,7,3.5 g.kg-1)的抗炎作用,采用扭体法和热板法评价其镇痛作用。结果:龙利叶水提液的LD50为68 g.kg-1,对二甲苯致小鼠耳廓肿胀、棉球致小鼠肉芽肿和角叉菜胶致大鼠足跖肿胀均有明显的抑制作用(P<0.05或P<0.01),能显著减少醋酸致小鼠扭体反应的次数(P<0.05或P<0.01),但不能提高小鼠的痛阈。结论:龙利叶水提液具有抗炎和镇痛作用,为龙利叶的开发和利用提供了科学依据。
Objective：To study anti-inflammatory and analgesic effect of water extract of Sauropus rostratus.Method： The LD50level of the water extract was determined by modified Karber’s method.Dimethylbenzene-induced auricle edema in mice,carrageenan-induced hind paw edema in rats and cotton ball-induced granuloma in mice were respectively performed to investigate the anti-inflammatory effect of the extract（14,7,3.5 g · kg-1）.Mouse twisting numbers induced by acetic acid and mouse pain threshold after heat stimulation on hot-plate tests were respectively performed to investigate the analgesic effect of S.rostratus.Result：The LD50level of water extract of S.rostratus.was 68 g · kg-1,the auricle edema induced by dimethylbenzene in mice,catton ball-induced granuloma in mice and carrageenan-induced hind paw edema in rats were inhibited significantly by water extract of S.rostratus.（P＆lt;0.05 or P＆lt;0.01）,water extract of S.rostratus could remarkably reduce mouse twisting numbers（P＆lt;0.05 or P＆lt;0.01）,but could not improve pain threshold.Conclusion：The water extract of S.rostratus had anti-inflammatory effect and analgesic effect,the researches could provide a scientific basis for developing and utilizing of S.rostratus.
出处
《中国实验方剂学杂志》
CAS
北大核心
2013年第9期270-273,共4页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西中医药大学科研课题(P2010043)
广西北海市科研项目(北科项00803001)
关键词
龙利叶
抗炎作用
镇痛作用
Sauropus rostratus
anti-inflammatory effect
analgesic effect
