摘要
目的探讨奥氮平联合无抽搐电休克治疗(modified electroconvulsive therapy,MECT)难治性精神分裂症的临床疗效及安全性。方法难治性精神分裂症80例,其中男48例,女32例;年龄28～65岁,病程6～32年,在服用奥氮平5～20 mg/d的基础上,联合MECT,观察6周。于联合治疗前及治疗后第1、2、4、6周末采用阳性与阴性症状量表(Positive and Negative Syndrome Scale,PANSS)、韦氏记忆量表(Wechsler Memory Scale,WMS)、治疗副反应量表(Treatment Emergent Symptom Scale,TESS)评定临床疗效及不良反应。以PANSS减分率作为疗效判定标准。结果痊愈3例,显著进步51例,进步19例,无效7例。显效率为67.5%,总有效率为91.3%。结论奥氮平联合MECT难治性精神分裂症疗效确切,安全性高。
）Objective Io explore the chncal efficacy and satety of the modifhed electroconvulsive therapy （MEcT） combined with olanzapine in the treatment of refractory schizophrenia. Methods A total of 80 cases with refractory schiz- ophrenia, including 48 males and 32 females of 28 to 65 years old and with 6 to 32 years of disease course, were studied. O- ral taking olanzapine 5-20 mg/d combined with MECT therapy and 6 weeks of observation were performed. Before treat- ment and at the 1st, 2a, 4th 6th weekend after treatment, Positive and Negative Symptom scale （PANSS）, Wechsler Memo- ry Scale （WMS） and Treatment Emergent Symptom Scale （TESS） were applied to assess the therapeutic efficacy and ad- verse reactions. The PANSS score was used as the criterion for the curative effect. Results Three cases were cured,51 ca- ses had significant improvement, 19 cases had improvement, and 7 cases had no improvement. The effective rate was 67. 5 % and the total effective rate was 91.3 %. Conclusion Modified electroconvulsive therapy combined with olanzapine is effective and safe in the treatment of refractory schizophrenia.
出处
《华南国防医学杂志》
CAS
2013年第4期251-253,共3页
Military Medical Journal of South China
关键词
奥氮平
无抽搐电休克
联合治疗
难治性精神分裂症
Olanzapine Modified electroconvulsive therapy Combination therapy Refractory schizophrenia
