摘要
目的探讨不同时长吸氧治疗对精神分裂症患者无抽搐电休克治疗(modified electroconvulsive therapy,MECT)后短时记忆的影响。方法选取精神分裂症160例,采用随机数字表法随机将其分为对照组、试验1组、试验2组及试验3组,各40例。4组均接受MECT。试验1、2、3组于MECT后分别给予20、40及60 min的吸氧治疗,对照组MECT后不进行吸氧治疗。观察比较4组治疗前、治疗后24 h及治疗后4周阳性与阴性症状量表(PANSS)评分及治疗前、治疗后24 h、治疗后1周、治疗后2周、治疗后4周记忆商数(MQ)值。结果各组内不同时间点PANSS评分总体比较差异具有统计学意义(P<0.05)。与本组治疗前比较,各组治疗后24 h和治疗后4周PANSS评分均降低;且与本组治疗后24 h比较,各组治疗后4周PANSS评分亦均降低,差异具有统计学意义(P<0.05)。各组内不同时间点MQ值总体比较差异具有统计学意义(P<0.05)。与本组治疗前比较,各组治疗后24 h MQ值均降低,差异具有统计学意义(P<0.05)。对照组MQ值于治疗后2周开始较治疗后24 h显著升高,试验1组MQ值于治疗后1周开始较治疗后24 h显著升高,差异均有统计学意义(P<0.05)。试验2组MQ值于治疗后1周开始较治疗后24 h显著升高,且治疗后1、2及4周较治疗前升高,差异均具有统计学意义(P<0.05)。试验3组MQ值于治疗后1周开始较治疗后24 h显著升高,且治疗后2周开始明显高于治疗前,差异均具有统计学意义(P<0.05)。治疗后1、2及4周,各组MQ值总体比较差异均有统计学意义(P<0.05),其中试验2组MQ值均明显高于对照组及试验1组,差异具有统计学意义(P<0.05)。结论精神分裂症患者MECT后持续吸氧40 min对短时记忆功能障碍改善效果最明显。
Objective To invstigate effect of different duration of oxygen therapy on short-term memory( STM) in patients with schizophrenia after modified electroconvulsive therapy( MECT). Methods A total of 160 patients with schizophrenia were divided into control group( n = 40),experiment group 1( n = 40),experiment group 2( n = 40) and experiment group 3( n = 40). All the patients received MECT. After MECT,experiment group 1,2 and 3 received oxygen therapy for 20 min,40 min,and 60 min respectively,while control group did not received oxygen therapy. Positive and negative syndrome scale( PANSS) scores before and at 24 h and in 4 weeks after treatment,and memory quotient( MQ) values before and at 24 h and in 1,2 and 4 weeks after treatment were observed and compared in four groups. Results There were significant differences in PANSS scores at different times in each group( P < 0. 05). Compared with those before treatment in the same group,PANSS scores at 24 h and in 4 weeks after treatment were significantly lower in each group,and the PANSS score in 4 weeks after treatment was significantly lower than that at 24 h after treatment in the same group( P < 0. 05). There were significant differences in MQ values at different times in each group( P < 0. 05). Compared with that before treatment in the same group,MQ value at 24 h after treatment was significantly lower in each group( P < 0. 05). Compared with those at 24 h after treatment,MQ value was significantly increasing in 2 weeks after treatment in control group,while the value was significantly increasing in 1 week after treatment in experiment group 1( P < 0. 05). In experiment group 2,MQ value was significantly increasing in 1 week after treatment compared with that at 24 h after treatment,and the values in 1,2 and 4 weeks after treatment were significantly increased compared with those before treatment( P < 0. 05). In experiment group 3,MQ value was increasing in 1 week after treatment compared with that at 24 h after treatment,and the value was significantly increased
出处
《临床误诊误治》
2018年第2期102-106,共5页
Clinical Misdiagnosis & Mistherapy
基金
北京市科学技术委员会首都临床特色应用研究项目(Z141107002514039)
关键词
精神分裂症
电休克
氧吸入疗法
记忆
短时
Schizophrenia
Electroshock
Oxygen inhalation therapy
Memory
short-term
