摘要
目的:通过对孕妇孕中期血清甲胎蛋白(AFP)、绒毛膜促性腺激素β亚单位(Freeβ-HCG)、游离雌三醇(uE3)检测,结合B超和羊水细胞染色体检查,进行以唐氏综合征(Down'sSyndrome,D'S)为主的疾病筛查。方法:采用芬兰Wallac公司提供的DELFIA试剂盒测定AFP、Freeβ-HCG及uE3值。结果:3142例孕中期孕妇中筛查出高风险196例,其中唐氏综合征高风险132例,18-三体高风险33例,神经管缺陷高风险31例。以35岁年龄为界分组相比较年龄大的孕妇组风险率显著增高。筛查后进行羊水细胞染色体检查98例,发现唐氏综合征2例,神经管缺陷高风险中做B超发现胎儿脊髓膨出1例。结论:孕中期进行产前筛查非常必要,对预防和减少出生缺陷有重要作用。
Objectives： To screen Down＇ s syndrome and the related disease by detecting maternal mid -pregnancy serum alpha - fetoprotein （ AFP）, human chorionic gonadotropin beta subunit （ Free β - HCG）, free three female alcohol （ uE3 ） , combining with B ultrasound and amniotic fluid chromosome examination. Methods： Determination of AFP, Free β -HCG and uE3 quantity by DELFIA kits provided by the Finland Wallac Company. Results： Among the 3142 cases, 196 cases were found out to be at high risk through the second trimester maternal screening, including 132 cases at high risk of Down＇ s syndrome, 33 cases of 18 - trisomy , 31 cases of neural tube defects. Pregnant women under 35 years old were at lower risk that those who were over 35. Among 98 cases which took amniotic fluid chromosome examination, 2 cases of Down＇ s syndrome were found out. One case was diagnosed as myelomeningocele by doing B ultrasound. Conclusion： It is of great importance to perform mid trimester prenatal screening so as to prevent and reduce born defects.
出处
《中国性科学》
2013年第4期18-19,22,共3页
Chinese Journal of Human Sexuality
关键词
产前筛查
孕中期
唐氏综合征
18-三体
神经管缺陷
Second trimester prenatal screening
Down＇ s syndrome
18 - trisomy
Neural tube defects
