摘要
目的 探讨基于基因检测指导下的叶酸个体化补充与辅助生殖助孕夫妇健康及胎儿发育之间的关系。方法回顾性分析2019年1月至2021年10月在我院生殖医学科行辅助生殖技术助孕的夫妇679例,自愿接受叶酸利用能力基因检测,并根据基因检测结果筛选出的中、高风险代谢能力的325例孕妇作为观察组,给于个体化叶酸补充,而选取未接受叶酸利用能力基因检测的354例孕妇作为对照组,仅给常规剂量的叶酸补充(400μg/d)。对比两组孕妇妊娠结束前血清内同型半胱氨酸(HCY)、血清叶酸含量,妊娠并发症以及胎儿结局情况。结果 观察组叶酸浓度为(26.37±8.23)nmol/L,Hcy浓度为(8.16±2.23)μmol/L均高于对照组的(23.23±8.15)nmol/L(10.43±2.38)μmol/L,差异有统计学意义(P<0.05)。对照组妊娠并发症186例,观察组妊娠并发症81例,差异有统计学意义(P<0.05)。观察组神经管缺陷性疾病的发生率明显低于对照组,差异有统计学意义(P<0.05)。结论 叶酸个体化补充可减少孕妇妊娠并发症和降低胎儿畸形的风险。
ObjectiveTo explore the relationship between individualized folic acid supplementation and the health of couples undergoing assisted reproductive technologyand fetal developmentbased on genetic testing.MethodsA total of 679couples who underwent assisted reproductive technology in the Department of Reproductive Medicine in Nanchang Reproductive Hospital from January 2019 to October 2021 were selected.Among the pregnant women who voluntarily received folic acid utilization ability gene detection,325 cases screened with medium and high risk of metabolic ability were selected as the observation group and were given individualized folic acid supplementation,while the 354 pregnant women who did not receive folic acid utilization ability gene detection were selected as the control group and were only given conventional doses of folic acid supplementation(400 μg/day).The serum homocysteine(HCY),serum folic acid content,pregnancy complications and fetal outcomes were compared between the two groups.ResultsThe folic acid concentration(26.37±8.23)nmol/L and HCY concentration(8.16±2.23)μmol/L in the observation group were significantly higher than those(23.23±8.15)nmol/L and(10.43±2.38)μmol/L in the control group(P<0.05).There were 186 cases of pregnancy complications in the control group and 81 cases in the observation group,and the differences were statistically significant(P<0.01).The incidence of neural tube defects in the observation group was significantly lower than that in the control group(P<0.05).ConclusionIndividualized folic acid supplementation can reduce pregnancy complications and the risk of fetal malformation.
作者
薛洁
李琳
张明亮
杨丽娟
陈韦君
宋莉
陈名
XUE Jie;LI Lin;ZHANG Mingliang;YANG Lijuan;CHEN Weijun;SONG Li;CHEN Ming(Nanchang Institute of Medical Science/Nanchang Xinhua Hospital,Nanchang 330001 China)
出处
《现代诊断与治疗》
CAS
2022年第22期3319-3322,共4页
Modern Diagnosis and Treatment
基金
江西省卫健委科技计划项目(202140193)。
关键词
叶酸利用能力
基因检测
个体化
辅助生殖技术
Folic acid utilization ability
Gene detection
Individualization
Assisted reproductive technology
