摘要
目的观察门冬氨酸鸟氨酸联合乙酰谷酰胺治疗肝性脑病患者的疗效。方法选择2006年1月至2010年1月山东省鄄城县人民医院住院的肝性脑病患者60例,按随机数字表法随机分为治疗组和对照组,每组各30例。治疗组30例肝性脑病患者在应用精氨酸的基础上,给予门冬氨酸鸟氨酸、乙酰谷酰胺治疗。对照组30例肝性脑病患者接受精氨酸治疗。两组患者治疗前与治疗后、治疗后组间血氨水平、谷丙转氨酶水平、血清总胆红素水平、白蛋白水平、清醒时间比较采用t检验;两组患者治疗总有效率比较采用χ2检验。结果治疗7 d后,治疗组29例患者(96.7%)神志转清,1例患者死亡;对照组19例患者(63.3%)神志转清,11例患者死亡。与治疗前比较,两组患者治疗后血氨水平、谷丙转氨酶水平、血清总胆红素水平均降低,白蛋白水平均升高,清醒时间均延长,且差异均有统计学意义(治疗组:t=5.427,7.565,3.415,-2.113,-14.598;对照组:t=2.958,4.258,2.541,-2.147,-15.478;均P<0.05)。治疗后,治疗组血氨水平、谷丙转氨酶水平、血清总胆红素水平低于对照组,白蛋白水平高于对照组,清醒时间短于对照组,且差异均有统计学意义(t=-5.258,-9.473,-3.419,-2.146,-3.597;均P<0.05)。治疗组总有效率96.7%(29/30)优于对照组63.3%(19/30),且差异有统计学意义(χ2=5.48,P<0.05)。结论门冬氨酸鸟氨酸联合乙酰谷酰胺是治疗肝性脑病的有效方法。
Objective To observe the effects of ornithine aspartate combined with aceglutamide in treating patients with hepatic encephalopathy. Methods Sixty cases of hepatic encephalopathy collected in Juancheng People＇s Hospital of Shandong from January 2006 to January 2010 were divided into treatment group and control group according to randomly digital table, with 30 cases in each group. Patients in both groups were treated with arginine,while patients in treatment group were given ornithine aspartate as well as aceglutamide additionally. Student＇s test was used to compare the levels of blood ammonia,glutamate pyruvate transaminase （GPT） ,serum total bilirubin （TBIL） ,albumin,and awake time before and after the treatment in each group, and between the two groups after the treatment. Chi-square test was used to compare the total effective rate of the two groups after treatment. Results After treatment for seven days, twenty-nine cases （96.7%） came conscious, and one case died in treatment group;Nineteen cases （63.3%） came conscious, eleven cases died in control group. As compared with pretreatment,the levels of blood ammonia, GPT, and TBIL in both groups were significantly decreased after treatment, and albumin, awake time in both groups were significantly increased （t = 5.427,7.565,3.415, -2. 113, - 14. 598 in treatment group;t = 2. 598,4.258,2. 541, - 2. 147, - 15. 478 in control group, all P 〈 0.05 ）. After the treatment, the levels of blood ammonia, GPT and TBIL in treatment group were significantly lower than those in control group,while albumin was higher,and the awake time was longer than that in control group significantly （t = - 5. 258, - 9. 473, - 3. 419, - 2. 146, - 3. 597, all P 〈0.05）. The total effective rate of treatment group was significantly higher than that of control group [96.7%（29/30）vs63.3% （19/30）,χ^2 = 5.48,P〈0.05]. Conclusion It is an effective method to combine ornithine aspartate with aceglutamide in treating patients with hepatic encephalopathy.
出处
《中华消化病与影像杂志（电子版）》
2012年第5期17-19,共3页
Chinese Journal of Digestion and Medical Imageology(Electronic Edition)
关键词
肝性脑病
鸟氨酸
酰胺类
治疗结果
Hepatic encephalopathy
Ornithine
Amides
Treatment outcome
