摘要
目的:观察前列地尔联合腺苷钴胺治疗老年2型糖尿病周围神经病变(DPN)的疗效。方法:选择老年2型糖尿病周围神经病变的患者58例,随机分为两组,治疗组29例(前列地尔联合腺苷钴胺治疗),对照组29例(腺苷钴胺治疗),两组血糖均控制在理想水平,治疗组予前列地尔10μg静脉推注,同时予腺苷钴胺1mg肌内注射,1次/d,连续治疗14d;对照组只给予腺苷钴胺1mg肌内注射,1次/d,连续治疗14d。两组均连续治疗2个疗程,共28d,观察治疗前后临床症状和神经电生理的变化。结果:临床症状有明显改善,治疗组总有效率为86.2%,对照组总有效率为51.7%,前列地尔联合腺苷钴胺治疗后神经传导速度明显(P<0.01),治疗组神经传导速度较对照组增快明显,两组间相比,差异有统计学意义(P<0.01)。结论:前列地尔联合腺苷钴胺治疗老年2型糖尿病周围神经病变,疗效显著优于腺苷钴胺单药治疗。
Objective：To observe the clinical efficacy of combined therapy of type 2 diabetic neuropathy in the elderly with Lipo PGE1 and cobamamide.Methods：58 aged patients with type 2 diabetic neuropathy were randomly divided into two groups,the treatment group which was treated with combination of Lipo PGE1（10 μg,i.v.） and cobamamide（1 mg,i.m.）,and the control group which was only administrated with cobamamide（1 mg,i.m.）.The blood glucose was adjusted to the ideal level.The two groups were both treated consecutively for 28 days.Results：The effective rates for treatment group and control group were 86.2% and 51.7% respectively.Statistical difference was found between two groups（P〈0.01）.Conclusion：Combined therapy for type 2 diabetic neuropathy in the elderly with Lipo PGE1 and cobamamide is much more efficacy than cobamamide therapy alone.
出处
《中国当代医药》
2010年第6期36-37,共2页
China Modern Medicine
