摘要
目的探讨着色性干皮病基因D(XPD)Lys751Gln多态性与非霍奇金淋巴瘤(NHL)临床表型及化疗疗效的相关性。方法收集87例广西NHL患者的外周血样本,检测XPD Lys751Gln位点的基因多态性,并分析各基因型与NHL临床表型及化疗疗效的相关性。结果①XPD Lys751Gln(T>G)多态性位点在87例NHL患者中的基因型频数分布为:T/T基因型71例(81.6%),T/G基因型16例(18.4%),未发现G/G基因型;②T/T及T/G基因型的频率在不同NHL细胞来源组、不同肿瘤恶性程度组、有无B症状组、不同国际预后指数组分布均无统计学差异(P>0.05);③T/T及T/G基因型的频率在化疗有效与无效患者之间的分布无统计学差异(P>0.05)。结论在中国广西NHL患者中,XPD基因Lys751Gln多态性与NHL不同临床表型(细胞来源、肿瘤恶性程度、有无B症状、危险程度)及化疗疗效均无统计学相关性。
Objective To explore the correlations between gene polymorphisms of xeroderma pigmentosum gene D （XPD） Lys751Gln and different clinical phenotypes and chemotherapeutic effects of non-Hodgkin＇ s lymphoma （NHL）. Methods Peripheral blood samples of 87 NHL patients from Guangxi of China were collected. The gene pol- ymorphism of XPD Lys751Gln was detected, and the correlations between different gene types, NHL clinical pheno- types and chemotherapeutic effects were analyzed. Results （~） Among 87 NHL patients, T/T and T/G genotypes of XPD Lys751 Gln（ T 〉 G） polymorphism sites were found in 71 cases （ 81.6 % ） and 16 cases （ 18.4 % ） respectively, but G/G genotype was not found. （~） TT and TG genotype frequencies of XPD Lys751Gln showed no significant differ- ences in the distributions of different NHL cell source groups, different malignant degree groups, with/without B symptom groups and different international prognostic index （IPI） groups （P 〉 0.05 ）. （3） The distributions of TT and TG genotype frequencies between NHL patients with/without chemotherapeutic effects had no significant differences （ P 〉 0.05 ）. Conclusion Among NHL patients from Guangxi of China, there are no conspicuous associations between the XPD Lys751 Gin polymorphism and different clinical phenotypes （ cell source, malignant degree of tumors, with/ without B symptom and dangerous degrees） and response to chemotherapy.
出处
《山东大学学报（医学版）》
CAS
北大核心
2013年第4期62-66,共5页
Journal of Shandong University:Health Sciences
基金
广西科学基金资助项目(桂科基0342010-7)
关键词
非霍奇金淋巴瘤
基因
着色性干皮病
单核苷酸多态性
Non-Hodgkin＇ s lymphomas
Gene
Xeroderma pigmentosum
Single nucleotide polymorphism
