摘要
目的分析广东省佛山市南海区第三人民医院金黄色葡萄球菌的耐药现状,为临床合理选用抗菌药物提供参考。方法收集2010年1月至2012年10月临床标本中分离的金黄色葡萄球菌,采用ATB new细菌鉴定分析仪进行鉴定和药敏试验,用K-B法进行耐甲氧西林金黄色葡萄球菌(MRSA)的筛查。结果 (1)共分离金黄色葡萄球菌336株,标本类型主要为痰、伤口分泌物和血液,分别占64.9%、14.9%和8.9%;(2)痰液是MRSA检出率最高的标本类型,检出的MRSA对大环内酯类、氨基糖苷类、喹诺酮类抗菌药物呈多重耐药,其耐药率均大于90%。未发现耐万古霉素和利奈唑胺的金黄色葡萄球菌。(3)重症监护室(ICU)与非ICU病区分离株的耐药性不同:ICU分离的菌株对各种抗菌药物的耐药率明显高于其他非ICU病区(P<0.01),MRSA中有53.2%分离自ICU病区。结论该院金黄色葡萄球菌引起的感染以肺部感染最常见,临床分离株对常用抗菌药物的耐药率每年呈上升趋势,MRSA表现为多药高度耐药,但对糖肽类药物敏感性高。ICU病区是耐药性监测的重点科室,需重点把关,以防多重耐药菌株在院内暴发流行。
Objective To investigate the current status about the drug resistance of Staphylococcus aureus. Methods The Staphylococcus aureus strains isolated from 2010 to 2012 were collected. All of the identification and drug susceptibility test were performed by ATB new analysis system. And the Methicillin resistant Staphylococcus aureus （MRSA） strains were maked sure by disk diffusion test. Results Sputum, wound secretions and blood sam- ples were the main source of S. aureus. The highest detection rate of MRSA was from sputum. Continuous monito- ring showed that MRSA were multi-drug resistant to macrolides,aminoglycosides and quinolones, and the resistance rates were all above 90.0%. No vancomycin-resistant strains and Linezolid -resistant strains were detected in 336 strains of S. aureus. 53.2% of MRSA were isolated from ICU patients, and the resistant rates of S. aureus strains in ICU patients were much higher than the other departments patients （P〈0.01）. Conclusion Lung infection is the most common infection caused by S. aureus, and its＂ resistant rate is increasing year by year. MRSA shows muti-re- sistant characteristics except Vancomycin. ICU needs more intentions to prevent the outbreak and prevalence of muti- drug resistant strains.
出处
《检验医学与临床》
CAS
2013年第8期931-932,935,共3页
Laboratory Medicine and Clinic
关键词
金黄色葡萄球菌
耐甲氧西林金黄色葡萄球菌
耐药性
Staphylococcus aureus
methicillin resistant staphylococcus aureus
drug resistance
