摘要
目的探讨西酞普兰与西酞普兰联合纳曲酮治疗酒精依赖伴抑郁患者的疗效及不良反应。方法将50例酒精依赖伴抑郁的患者随机分为西酞普兰组(A组)和西酞普兰联合纳曲酮组(B组),疗程12周;于治疗前及治疗后2、4、6、8、12周进行相关量表评定并对比两组间的疗效与不良反应。结果西酞普兰与西酞普兰联合纳曲酮对酒精依赖伴抑郁患者抑郁症状的改善均有明显效果,无统计学意义(P>0.05);但西酞普兰联合纳曲酮能明显降低患者对酒精的渴求程度,能降低复饮率,统计学上存在显著性差异(P<0.05);两组间不良反应无显著差异(P>0.05)。结论西酞普兰联合纳曲酮治疗酒精依赖伴抑郁的患者安全有效。
Objective To investigate the treatment efficacy and the adverse effects of citalopram and citalopram com- bined with nahrexone for alcohol dependent patients with depression. Methods 50 cases of alcohol dependent patients with depression randomly divided into citalopram group （group A） and citalopram combined with naltrexone group （group B）, and set the treatment period to 12 weeks; evaluated and compared the efficacy and adverse effects separately before treatment and when after 2,4,6,8 and 12 weeks. Results Citalopram and citalopram combined with naltrexone had prominent improvement in patients＂ symptoms, there was not statistically significance; however citalopram combined with naltrexone could significantly lowered the alcohol craving of patients,reduced the re-drinking rate,there was significant statistical difference （P〈0.05） ; the adverse effects between group A and group B had no significant statistical difference （P〈0.05）. Conclusion Citalopram combined with nahrexone have safe treatment efficacy for alcohol dependent patients with depression.
出处
《中国现代医药杂志》
2013年第4期36-38,共3页
Modern Medicine Journal of China
关键词
西酞普兰
纳曲酮
酒精依赖
抑郁
Citalopram Nahrexone Alcohol dependence Depression
