摘要
近年来深部真菌感染的发病率显著上升,而目前临床可用的抗真菌药有限,新药研发难度大,因此联合用药有望成为抗真菌治疗的理想选择。植物成分以单体或混合物的形式与抗真菌药物协同发挥抗真菌的作用,已在体外实验中有比较广泛和深入的研究,但体内抗真菌实验、机制研究和临床试验有待进一步探究。该文就植物成分协同抗真菌作用及其机制的研究进展进行了综述,旨在为新型抗真菌药物的研究提供参考。
The incidence of systemic fungal infections have increased dramatically in recent years, but now clinically available antifungal drugs are limited, and the research and development of new drugs are difficult. So combination therapy is expected to be- come the ideal choice for antifungal therapy. Plant compositions can play a synergistic antifungal effect with the antifungal agents in the form of a monomer or mixture. Such research is more extensive and thorough in vitro , but further study on the antifungal effects in vivo , mechanisms and clinical trials is still needed. This review focuses on the antifungal synergism of plant compositions combined with antifungal agents, so as to provide a reference for the study of the novel antifungal drugs.
出处
《中国真菌学杂志》
CSCD
2013年第1期55-60,共6页
Chinese Journal of Mycology
基金
国家自然科学基金(81173635
81273556)
关键词
植物成分
协同
抗真菌
机制
plant composition
synergism
antifungal effect
mechanisms
