摘要
综述中药抗念珠菌现状及抑菌机制研究进展。研究表明中药中某些单体成分、提取物及复方均能抑制致病念珠菌生长,可以抑制其毒力因子(水解酶、菌丝、生物膜)活性及相关基因的表达,或促进内源性活性氧的生成,从而加重菌体细胞氧化损伤。
This paper reviews the mechanisms and progress of Chinese medicine against Candida. Studies have shown that some monomer components,extracts,and prescriptions of traditional Chinese medicine can inhibit the growth of pathogenic Candida. Besides restraining the expression of virulence factors(hydrolase,mycelium,biofilm)and related genes,they can promote the production of endogenous reactive oxygen species and aggravate the oxidative damage of yeast cells.
作者
李贞
陈伟琴
胡骏
殷红梅
彭奕冰
胡晓波
LI Zhen;CHEN Weiqin;HU Jun;YIN Hongmei;PENG Yibing;HU Xiaobo(Department of clinical laboratory,Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Department of Laboratory Medicine,Ruijin Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200025,China)
出处
《上海中医药杂志》
2019年第12期83-88,92,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金面上项目(81572053)
上海中医药大学附属龙华医院国家中医临床研究基地龙医学者项目(育苗计划LYTD-66)
关键词
念珠菌
中草药
单体
机制研究
综述
Candida
traditional Chinese medicine
monomer
mechanism research
review
