摘要
从半合成原料、菌种选育及改良和生物转化新技术与新工艺(包括底物的物理/化学助溶法,新型转化体系和细胞通透性改良法)等方面对近几年来甾体生物转化进展进行综述。可以预测,在甾体药物的工业化生产过程中,生物转化技术所占比例将大幅度提高。
Progress of biotransformation technology of steroid compounds was reviewed. The selection of steroid raw materials, selection and improvement of microbial strain and new technologies of biotransformation were discussed, including physical/chemical solubilizing of substrates, new transformation system and improvement of cell permeability. It is forecasted that the proportion of biotransformation technologies increased in the industrial production process of steroid hormone drugs.
出处
《生物加工过程》
CAS
CSCD
2013年第2期30-36,共7页
Chinese Journal of Bioprocess Engineering
基金
国家高技术研究发展计划(863计划)重大项目(2011AA02A211)
国家自然科学基金(21206055)
江苏省自然科学基金(BK2012127)
关键词
甾体
生物转化
药物中间体
steroids
biotransformation
pharmaceutical intermediates
