摘要
目的研究因颅脑外伤后引起的迟发性顽固性癫痫的发病基础及最佳手术方式。方法选取我院收治的因颅脑外伤引起的迟发性癫痫的患者50例,作为研究对象随机分成A组和B组,各25例,分别采用不同的手术方式,A组采用常规的病理灶切除术,B组在A组的基础上配合标准前颞叶切除术,手术后随访6～12个月,根据疗效评价标准比较两组患者术后的疗效。根据引起颅脑外伤的病因及术后病理分析颅脑外伤引起的迟发性癫痫病变组织的病理特点,研究其发病基础。结果根据引起颅脑外伤的病因和术后病理分析,其发病基础主要为外伤造成的脑叶软化灶形成和瘢痕增生;手术后随访6～12个月,其中A组总有效率为60%,B组总有效率占92%,P均<0.05,具有统计学意义。结论颅脑外伤后迟发性顽固性癫痫的主要发病基础是外伤造成的脑软化灶和瘢痕增生。B组的手术方式能够有效提高治疗的效果,是颅脑外伤后迟发性顽固性癫痫患者选择的最佳手术方式,手术随访疗效显著。
Objective To study for craniocerebral trauma caused by delay sex with intractable epilepsy pathogenesis of foundation and the best operation method. Methods The patients of craniocerebral trauma for our cause delay epilepsy patients 50 cases, as the research object random divided into group A and group B, each 25 cases, we adopt different operation method; A group of using conventional pathology stove resection, group B in group A with standard on the basis of former temporal lobectomy, surgery were followed up for 6 - 12 months, according to curative effect evaluation standard compared between the two groups patients postoperative effect. According to the etiology of craniocerebral trauma caused and postoperative pathologic analysis craniocerebral trauma caused by the late-occurred epilepsy variable tissue pathological characteristics, study the onset of foundation. Results According to cause craniocerebral trauma and the causes of postoperative pathological analysis, the onset of foundation is mainly caused by trauma of lobes softening stove formation and scar hyperplasia; After surgery were followed up for 6 ~ 12 months, the total effective rate was 60% in group A, B group total effectiveness 92%, P〈0.05, with statistical significance. Conclusion Craniocerebral trauma with intractable epilepsy late-occurred the main disease caused by trauma is based on the encephalomalacia stove and scar hyperplasia. B group of operation method can effectively enhance the treatment effect, is after craniocerebral trauma with intractable epilepsy late-occurred patients to choose the best operation method, surgery follow-up curative effect is distinct.
出处
《中国医药指南》
2013年第4期20-21,共2页
Guide of China Medicine
关键词
颅脑外伤
癫痫
发病基础
手术方式
Craniocerebral trauma
Epilepsy
The foundation
Operation method
