左西替利嗪与变应性鼻炎被引量：2

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摘要 1哌嗪类抗组胺药物与变应性鼻炎抗组胺药主要是指组胺H1受体拮抗剂，被广泛用于治疗变应性鼻炎（AR）及荨麻疹等变应性疾病。临床应用的抗组胺药物中，哌嗪类药物占有很大比例。在第1代哌嗪类抗组胺药物中，代表药物为羟嗪及去氢羟嗪，因其中枢神经抑制作用及抗胆碱能效应等副作用的发现，逐渐广泛被第2代抗组胺药物所取代；在第2代哌嗪类抗组胺药物中，以西替利嗪为典型代表，其不经过肝脏代谢，无潜在的药物相互作用而广泛应用。随着对药物的不断开发研制，第2代新型哌嗪类抗组胺药物左西替利嗪于21世纪初上市，因临床疗效好及安全性高的特点逐步用于临床。

作者陈冬隋丽

机构地区辽宁医学院附属第一医院耳鼻咽喉头颈外科辽宁医学院

出处《中国医学文摘（耳鼻咽喉科学）》 2013年第2期94-95,共2页 Chinese Medical Digest(Otorhinolaryngology)

基金辽宁省博士科研启动基金(20101063)

关键词鼻炎变应性季节性组胺H1拮抗剂西替利嗪左西替利嗪

分类号 R765.21 [医药卫生—耳鼻咽喉科]

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