摘要
目的:比较2型糖尿病患者(DM)、2型糖尿病伴牙周病患者(DM&AP)及牙周病患者(AP)龈沟液(GCF)中的白细胞介素-1β(IL-1β)水平,探讨DM和DM&AP糖化血红蛋白(HbA1c)浓度与IL-1β的相关性。方法:使用滤纸条法采集GCF,DM、DM&AP、AP患者及正常对照组各30例;ELISA法测定GCF中IL-1β含量;运用高效液相层析法测定DM和DM&AP的糖化血红蛋白水平。结果:DM、DM&AP、AP的GCF量和IL-1β量均高于正常对照组(P<0.05);DM&AP、AP组GCF量显著高于DM组(P<0.05);DM&AP组IL-1β含量高于DM组和AP组(P<0.05)。结论:糖尿病患者和糖尿病伴牙周病患者IL-1β均高于正常人,长期的高血糖会使糖尿病患者易患牙周病,提示糖尿病患者在关注血糖控制的同时还要高度关注牙周健康。
Objective： To compare the different level of IL-1β in gingival crevicular fluid （GCF）among type 2 diabetes mellitus patients （DM） ,type 2 diabetes mellitus with periodontal diseases patients （DM＆AP） and periodontal diseases patients （AP）, we investigated the relationship between concetration of HbAlc and IL-1β in DM and DM＆AP. Method： GCF were collected by filter strips.DM, DM ＆ AP, AP patients and normal control group of 30 patients in each were included in this study. Their IL-1β were measured by ELASA,HbAlc in DM and DM＆AP were detected by High Performance Liquid Chromatography. Result： The diabetics, diabetics with periodontal diseases and periodontal diseases patients had higher GCF and IL-1β than normal control group （P 〈0.05）. The diabetics with periodontal diseases and periodontal diseases patients had higher GCF than the diabetics group （P 〈0.05）. The diabetics with periodontal diseases had higher IL-1β than the diabetics group and periodontal diseases patients （P 〈0.05）. Conclusion： The diabetics and diabetics with periodontal diseases patients have higher IL-1β than normal. Long-term hyperglycemia causes diabetic patients susceptible to periodontal disease. So diabetic patients should highly concerned about periodontal health as they control blood suger.
出处
《临床口腔医学杂志》
2013年第4期231-233,共3页
Journal of Clinical Stomatology
基金
陕西省自然科学基金项目(2002C245)
关键词
白细胞介素-1Β
2型糖尿病
牙周病
糖化血红蛋白
Interleukin-1β
type 2 Diabetes mellitus
periodontal disease
G1ycosvlated hemoglobin
