摘要
目的探讨高尿酸血症对于45岁以下冠状动脉粥样硬化性心脏病（冠心病）患者的风险意义。方法回顾677例45岁以下冠心病患者，分为高尿酸组（164例）和正常尿酸组（513例），分析高尿酸组冠心病患者的临床特点，以及高尿酸血症对冠状动脉病变严重性的独立风险。采用t检验X^2检验和Lgistic回归分析进行统计分析。结果与正常尿酸组冠心病患者比较，高尿酸组冠心病患者男性多见，多伴发高血压[分别为197例（38．5％）和93例（56．7％）；X^2=16．85，P〈O．01]、高血脂[分别为274例（53．4％）和130例（80．7％）；X^2=37．58，P〈0．01]、心功能不全[分别为24例（4．7％）和17例（10．4％）；X^2=7．18，P=-0．01]。多因素回归分析显示，高尿酸血症增加了冠心病并发心功能不全[OR1校正＝2．66，95％CI（1．28，5．53）]、心律失常[OR2校正=1．28，95％CI（1．00，1．65）]的风险。结论高尿酸血症是45岁以下冠心病患者发生心功能不全、心律失常的危险因素。
Objective To evaluate the risk of hyperuricemia in patients younger than 45 with coronary artery disease. Methods Six hundred and seventy-seven patients with coronary artery disease under 45 years old at disease onset were recruited retrospectively. The subjects were divided into hyperuricemia group （n= 164） and normal uric acid group （n=513）. Patients with coronary artery disease with hyperuricemia were analyzed for clinical characteristics. The risk of hyperuricemia was analyzed on the severity of coronary lesions. T-test, X2 test and Logistic regression analysis were used for statistical analysis. Results Comparing with patients with normal uric acid, patients in the hyperuricemia group were male predominant and more prevalent with hypertension [ 197（38.5%） and 93（56.7%）; X2=16.85, P〈0.01 ], hyperlipidemia [274（53.4%） and 130 （80.7%）; X2=37.58, P〈0.01], and cardiac dysfunction [24（4.7%） and 17（10.4%）; X2=7.18, P=0.01]. Hyperuricemia increased the risk of coronary artery disease complicated with cardiac dysfunction [OR= 2.66, 95%CI （1.28,5.53）, and it also increased the risk of coronary artery disease concurrent with cardiac arrhythmia [OR2=1.28, 95%C1 （1.00,1.65） ] revealed by multivariate regression analysis. Conclusion In young patients under 45 years old with coronary artery disease, hyperuricemia is the independent risk factor for coronary artery disease complicated with cardiac dysfunction and arrhythmia.
出处
《中华风湿病学杂志》
CAS
CSCD
北大核心
2013年第4期250-254,共5页
Chinese Journal of Rheumatology
