摘要
目的探讨高血压病合并高尿酸血症在冠心病患病风险及冠状动脉病变程度评估中的价值。方法选取临床疑诊冠心病的患者662例,根据高血压病与高尿酸血症的发病情况分为高血压病合并高尿酸血症组、单纯高血压病组、单纯高尿酸血症组、无高血压病及高尿酸血症组。所有患者行冠状动脉造影并依据冠状动脉病变程度分为冠心病组和非冠心病组,对冠状动脉病变程度的评估应用Gensini评分方法,观察高血压病合并高尿酸血症与冠心病的关系。结果冠心病组患者血尿酸水平(358.1±95.1μmol/L)、高尿酸血症(30.8%)及高血压病(52.6%)患病率高于非冠心病组(P<0.05)。高血压病、高尿酸血症是冠心病患病有意义的预测因子,二者存在交互作用,OR为1.17。高尿酸血症合并高血压病的冠心病患者Gensini评分显著升高。高血压病合并高尿酸血症的患病率与冠状动脉病变血管支数存在趋势性关系。结论联合应用血尿酸与高血压病对冠状动脉病变程度及患病风险评估可能有一定临床意义。
Aim To investigate the value of hypertension with hyperuricemia for the assessment of the presence and severity of coronary artery disease （CAD）. Methods The association between hyperuricemia with hypertension and the presence and severity of coronary artery disease was investigated in 662 patients with clinically suspected coronary artery disease. According to the incidence of hypertension and hyperuricemia all patients were divided into four groups. They were 91 cases of hypertension with hyperuricemia, 259 cases of hypertensive patients. Hyperuricemia alone were 77 cases, and no disease of hyperuricemia and high blood pressure were 235 cases. All patients who underwent coronary angiography were divided into 458 cases of CAD group and 204 cases of non-CAD group based on the severity of coronary artery disease. Severity of coronary artery disease was evaluated using the Gensini score index. Results The serum u- ric acid levels （358.1 ± 95.1 μmoL/L） and the prevalence of hypertension （52. 6% ） and hyperurieemia（30. 8% ） were higher in CAD patients than those in without CAD （P 〈 0. 05 ）. There were interactions between hyperuricemia and hypertension which were significant predictors for present of CAD. The Gensini scores of CAD patients who complicated with both hyperurieemia and hypertension were the highest. There was a linear trend between higher prevalence of hypertension with hyperuricemia and increasing numbers of disease vessel. Coulusion Serum uric acid in combination with hypertension may have some clinical significance in evaluating the degree and risk of coronary artery disease.
出处
《中国动脉硬化杂志》
CAS
CSCD
北大核心
2011年第4期339-342,共4页
Chinese Journal of Arteriosclerosis
关键词
冠心病
高血压病
高尿酸血症
Coronary Artery Disease
Hypertension
Hyperuricemia
