摘要
目的探讨原发性肝癌(PHC)合并肝硬化与无肝硬化患者年龄及HBV血清学特点。方法回顾性分析经影像学检查及甲胎蛋白(AFP)测定诊断为PHC的患者547例,分为有肝硬化和无肝硬化两组,统计分析并比较其年龄分布及HBV血清学标记的特点。结果合并肝硬化与无肝硬化患者分别为265例及282例,两组伴HBV感染者分别为221例、256例。合并肝硬化的肝癌患者男女比例为7.83∶1;60岁以下的男性肝癌患者年龄分布无明显差异,无肝硬化的男性肝癌患者60岁以上比例明显高于有肝硬化者(P<0.005)。合并肝硬化的男性肝癌患者HBV感染率40岁以下年龄组最高(96.67%),而HBeAg血清学转换率以40～60岁年龄段最高(89.47%);无肝硬化者HBV感染率40～60岁年龄段最高(90.43%),但HBeAg血清学转换率最低(80%)。结论合并肝硬化的PHC患者中,男性占大多数,而且早年HBV感染率高;无肝硬化的PHC患者中,老年人占多数;HBeAg血清学转换率高的人群肝癌发病率相对较高。
Objective To compare the age distributions and presence of hepatitis B virus（HBV） serological markers between primary hepatic cancer（PHC） patients with and without liver cirrhosis.Methods A total of 547 PHC cases were analyzed retrospectively.After dividing into two groups according to liver cirrhosis status,the between-group differences in age and HBV serological markers,such as hepatitis B e antigen（HBeAg） status,were statistically compared using the Chi-squared test.Results The number of cirrhotic and non-cirrhotic PHC patients was 265 and 282,respectively.HBV infection was present in 221 cirrhotic PHC patients and 256 non-cirrhotic PHC patients（83.4% vs.90.8%）.There was a substantial bias in the proportion of males to females in the cirrhotic PHC patients（7.83∶ 1）.The number of PHC patients 60 years old was similar between the cirrhotic and non-cirrhotic groups,but the non-cirrhotic group had significantly more patients 60 years old（P0.005）.In cirrhotic PHC patients,the HBV infection rate was highest in the 40 years old age group（96.7%） and the HBeAg serological conversion rate was highest in the 40-60 years old age group（89.5%）.In non-cirrhotic PHC patients,the 40-60 years old age group showed the highest HBV infection rate（90.3%） but the lowest HBeAg serological conversion rate（80.0%）.Conclusion PHC with liver cirrhosis mainly occurred in males,with the HBV infection rate being higher in individuals 60 years old.Non-cirrhotic PHC patients were more often 60 years old.Many of the HBV-infected PHC patients with cirrhosis had high HBeAg serological conversion rate.
出处
《临床肝胆病杂志》
CAS
2013年第3期214-216,共3页
Journal of Clinical Hepatology
基金
江苏省预防医学科研基金(Y201032)
关键词
肝肿瘤
肝硬化
肝炎
乙型
慢性
肝炎病毒
乙型
liver neoplasms
liver cirrhosis
hepatitis B
chronic
hepatitis B virus
