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肾脏有机阴离子转运体在尿酸转运中的作用研究进展 被引量:8

Role of renal organic anion transporter in the transport of uric acid
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摘要 尿酸是嘌呤核苷酸类和游离碱基转化过程中的最终酶产物,肾脏有机阴离子转运体在维持体内尿酸的重吸收与分泌之间的平衡有显著性意义。尿酸的重吸收和分泌失衡是导致高尿酸血症的主要原因。研究肾脏有机阴离子转运体在尿酸转运中的作用有重要意义。 Uric acid is a final enzymatic product in the degradation of purine nucleosides and free bases in humans.Renal organic anion transporters maintain significantly the balance between re-absorption and secretion of the organic anion.The main reason for hyperuricemia is the imbalance of uric acid re-absorption and secretion.So we elucidate renal organic anion transporter in the transport of uric acid.
出处 《安徽医药》 CAS 2013年第3期361-364,共4页 Anhui Medical and Pharmaceutical Journal
基金 广东省科技计划重大专项(No 2012A080201012) 广州市科技计划项目(No 2010GN-E00221) 广东医院制剂研究开发技术平台建设(No 2011A080300004)
关键词 尿酸 有机阴离子转运体 重吸收 分泌 uric acid organic anion transporter re-absorption secretion
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